Escande D, Thuringer D, Leguern S, Cavero I
Laboratory of Cellular Electrophysiology, Rhône-Poulenc Santé, Gennevilliers, France.
Biochem Biophys Res Commun. 1988 Jul 29;154(2):620-5. doi: 10.1016/0006-291x(88)90184-2.
In cardiac myocytes, cromakalim (BRL 34915), a potassium channel opener, activates a time-independent K+ current exhibiting poor voltage-sensitivity. This effect of cromakalim is antagonized by low concentrations of glibenclamide, a specific blocker of ATP-dependent K+ channels in cardiac cells. Direct recording of the activity of K+ channels in inside-out membrane patches, confirmed that cromakalim is a potent activator of ATP-dependent K+ channels in cardiac myocytes.
在心肌细胞中，钾通道开放剂色满卡林（BRL 34915）可激活一种电压敏感性较差的非时间依赖性钾电流。色满卡林的这种作用可被低浓度的格列本脲拮抗，格列本脲是心肌细胞中ATP依赖性钾通道的特异性阻滞剂。对内膜向外膜片上钾通道活性的直接记录证实，色满卡林是心肌细胞中ATP依赖性钾通道的有效激活剂。
