Psychophysiology and Optical Imaging, Department of Psychiatry and Psychotherapy, University of Tuebingen Tuebingen, Germany ; Hitachi, Ltd., Central Research Laboratory Hatoyama, Japan.
Psychophysiology and Optical Imaging, Department of Psychiatry and Psychotherapy, University of Tuebingen Tuebingen, Germany ; LEAD Graduate School, University of Tuebingen Tuebingen, Germany.
Front Hum Neurosci. 2014 Feb 6;8:37. doi: 10.3389/fnhum.2014.00037. eCollection 2014.
Previous studies have suggested complex interactions of mood and cognition in the lateral prefrontal cortex (PFC). Although such interactions might be influenced by various factors such as personality and cultural background, their reproducibility and generalizability have hardly been explored. In the present study, we focused on a previously found correlation between negative mood states and PFC activity during a verbal working memory (WM) task, which had been demonstrated by using near-infrared spectroscopy (NIRS) in a Japanese sample. To confirm and extend the generalizability of this finding, we conducted a similar experiment in a German sample, i.e., participants with a different language background. Here, PFC activity during verbal and spatial WM tasks was measured by NIRS using a delayed match-to-sample paradigm after the participants' natural mood states had been evaluated by a mood questionnaire (Profiles of Mood States: POMS). We also included control tasks to consider the general effect of visual/auditory inputs and motor responses. For the verbal WM task, the POMS total mood disturbance (TMD) score was negatively correlated with baseline-corrected NIRS data mainly over the left dorsolateral PFC (i.e., higher TMD scores were associated with reduced activation), which is consistent with previous studies. Moreover, this relationship was also present when verbal WM activation was contrasted with the control task. These results suggest that the mood-cognition interaction within the PFC is reproducible in a sample with a different language background and represents a general phenomenon.
先前的研究表明，情绪和认知在外侧前额叶皮层（PFC）中存在复杂的相互作用。尽管这种相互作用可能受到个性和文化背景等各种因素的影响，但它们的可重复性和普遍性几乎没有得到探索。在本研究中，我们专注于之前使用近红外光谱（NIRS）在日本样本中发现的负性情绪状态与言语工作记忆（WM）任务期间 PFC 活动之间的相关性。为了确认和扩展这一发现的普遍性，我们在德国样本中进行了类似的实验，即参与者具有不同的语言背景。在这里，使用延迟匹配样本范式，通过 NIRS 测量言语和空间 WM 任务期间的 PFC 活动，在参与者的自然情绪状态通过情绪问卷（情绪状态简表：POMS）进行评估后。我们还包括控制任务，以考虑视觉/听觉输入和运动反应的一般影响。对于言语 WM 任务，POMS 总情绪干扰（TMD）评分与基线校正后的 NIRS 数据呈负相关，主要分布在左侧背外侧 PFC 上（即，TMD 评分越高，激活程度越低），这与先前的研究一致。此外，当将言语 WM 激活与对照任务进行对比时，这种关系仍然存在。这些结果表明，在具有不同语言背景的样本中，PFC 内的情绪-认知相互作用具有可重复性，代表一种普遍现象。
