1 Department of Respiration, General Hospital of Jinan Military Command , Jinan, People's Republic of China .
DNA Cell Biol. 2014 May;33(5):320-7. doi: 10.1089/dna.2013.2273. Epub 2014 Feb 25.
Abnormal regulation of apoptosis can lead to carcinogenesis. Single nucleotide polymorphisms in apoptotic genes have been associated with cancer risk, such as the FAS rs2234767G/A polymorphism, which alters transcription of the FAS promoter. Downregulation of FAS, with resultant cellular resistance to death signals, has been found in many cancers. However, the association between the FAS rs2234767G/A polymorphism and cancer risk is still controversial. Here, we performed a meta-analysis including 41 articles (44 case-control studies, 17,814 cases and 24,307 controls) identified from PubMed and Chinese language (CNKI and WanFang) databases related to cancer susceptibility and the FAS rs2234767G/A polymorphism. We used odds ratios (ORs) and 95% confidence intervals (CIs) to assess the strength of the associations. We found that the rs2234767 G-allele was a protective factor for cancer risk (GG vs. AA: OR=0.88, 95% CI=0.79-0.98; GG+GA vs. AA: OR=0.87, 95% CI=0.79-0.96). Similar associations were detected in the "source of control", ethnicity, and cancer type subgroups. Further studies on a larger sample size and considering gene-environment interactions should be conducted to confirm the role of FAS polymorphisms, especially rs2234767G/A, in cancer risk.
凋亡的异常调节可导致癌变。凋亡基因的单核苷酸多态性与癌症风险相关，例如 FAS rs2234767G/A 多态性，它改变了 FAS 启动子的转录。在许多癌症中发现 FAS 的下调，导致细胞对死亡信号的抵抗。然而，FAS rs2234767G/A 多态性与癌症风险之间的关联仍存在争议。在这里，我们进行了一项荟萃分析，包括从 PubMed 和中文（CNKI 和万方）数据库中确定的 41 篇文章（44 项病例对照研究，17814 例和 24307 例对照），这些文章与癌症易感性和 FAS rs2234767G/A 多态性相关。我们使用比值比（OR）和 95％置信区间（CI）来评估关联的强度。我们发现 rs2234767 G-等位基因是癌症风险的保护因素（GG 与 AA：OR=0.88，95％CI=0.79-0.98；GG+GA 与 AA：OR=0.87，95％CI=0.79-0.96）。在“对照来源”、种族和癌症类型亚组中也检测到了类似的关联。应该进行更大样本量的进一步研究，并考虑基因-环境相互作用，以确认 FAS 多态性（尤其是 rs2234767G/A）在癌症风险中的作用。
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