Wang Jianguo, Huang Pinghua, Zhao Wei, Ren Wei, Ai Ling, Wu Liping
Department of Prenatal Diagnostic, Jiaxing Maternity and Children Health Care Hospital, Jiaxing University, Jiaxing, Zhejiang, China.
J Int Med Res. 2020 Aug;48(8):300060520947937. doi: 10.1177/0300060520947937.
The aim of the study was to quantitatively assess the association of metallothionein 2A () polymorphisms rs28366003 and rs1610216 with cancer risk.
Crude odd ratios (OR) with 95% confidence intervals (CI) were used to estimate associations of the polymorphisms with cancer risk.
Six eligible case-control studies with 1899 cases and 2437 controls focused on rs28366003, and three of those six studies, with 548 cases and 926 controls, additionally focused on rs1610216. Pooled analysis showed that rs28366003 and rs1610216 were associated with cancer risk: (AG + GG) vs. AA, OR = 2.67; GG vs. (AG + AA), OR = 5.97; GG vs. AA, OR = 6.80; AG vs. AA, OR = 2.46; G vs. A, OR = 2.67 for rs28366003; and CC vs. (TC+TT), OR = 2.51; CC vs. TT, OR = 2.42 for rs1610216. Subgroup analysis based on ethnicity showed a significant association of rs28366003 with cancer risk in Asian and Caucasian populations. However, a significant association of rs1610216 with cancer risk was found only in the Asian population.
rs28366003 and rs1610216 polymorphisms were associated with cancer risk and might serve as genetic biomarkers for predicting cancer risk. However, larger studies are needed to confirm these findings.
本研究旨在定量评估金属硫蛋白2A（MT2A）基因多态性rs28366003和rs1610216与癌症风险的关联。
采用粗比值比（OR）及95%置信区间（CI）来估计多态性与癌症风险的关联。
六项符合条件的病例对照研究（共1899例病例和2437例对照）聚焦于rs28366003，其中三项研究（共548例病例和926例对照）还额外聚焦于rs1610216。汇总分析显示，rs28366003和rs1610216与癌症风险相关：对于rs28366003，（AG + GG）与AA相比，OR = 2.67；GG与（AG + AA）相比，OR = 5.97；GG与AA相比，OR = 6.80；AG与AA相比，OR = 2.46；G与A相比，OR = 2.67；对于rs1610216，CC与（TC + TT）相比，OR = 2.51；CC与TT相比，OR = 2.42。基于种族的亚组分析显示，rs28366003在亚洲和白种人群中与癌症风险存在显著关联。然而，仅在亚洲人群中发现rs1610216与癌症风险存在显著关联。
rs28366003和rs1610216多态性与癌症风险相关，可能作为预测癌症风险的遗传生物标志物。然而，需要更大规模的研究来证实这些发现。
