甲状腺髓样癌患者及其家庭成员淋巴细胞中的自发和诱导染色体损伤。
Spontaneous and induced chromosome damage in lymphocytes of medullary thyroid carcinoma patients and their family members.
作者信息
Tsioupra K, West L F, Davis M B, Parrington J M, Delhanty J D
机构信息
University College London, Department of Genetics and Biometry.
出版信息
Dis Markers. 1988 Jun;6(2):127-32.
Detailed chromosome analysis failed to reveal any evidence for spontaneous chromosome instability in lymphocytes from patients with multiple endocrine neoplasia, type 2 (MEN-2), whereas, with one exception, lymphocytes from MEN-2 patients were significantly more sensitive to chromosome damage by bleomycin and, to a lesser extent, MNNG than those from controls. The exceptional case suggests possible genetic heterogeneity in MEN-2.
详细的染色体分析未能揭示2型多发性内分泌腺瘤病（MEN-2）患者淋巴细胞中存在任何自发染色体不稳定的证据，然而，除了一个例外，MEN-2患者的淋巴细胞对博来霉素诱导的染色体损伤显著更敏感，对N-甲基-N'-硝基-N-亚硝基胍（MNNG）诱导的染色体损伤也较对照组更敏感，但程度稍轻。这个例外情况提示MEN-2可能存在基因异质性。
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