Lawn Will, Barratt Monica, Williams Martin, Horne Abi, Winstock Adam
Clinical, Educational and Health Psychology, University College London, London, UK
National Drug Research Institute, Curtin University, Perth, WA, Australia.
J Psychopharmacol. 2014 Aug;28(8):780-8. doi: 10.1177/0269881114523866. Epub 2014 Feb 24.
The NBOMe compounds are a novel series of hallucinogenic drugs that are potent agonists of the 5-HT2A receptor, have a short history of human consumption and are available to buy online, in most countries. In this study, we sought to investigate the patterns of use, characteristics of users and self-reported effects. A cross-sectional anonymous online survey exploring the patterns of drug use was conducted in 2012 (n = 22,289), including questions about the use of 25B-NBOMe, 25C-NBOMe, and 25I-NBOMe and comparison drugs. We found that 2.6% of respondents (n = 582) reported having ever tried one of the three NBOMe drugs and that at 2.0%, 25I-NBOMe was the most popular (n = 442). Almost all (93.5%) respondents whose last new drug tried was a NBOMe drug, tried it in 2012, and 81.2% of this group administered the drug orally or sublingually/buccally. Subjective effects were similar to comparison serotonergic hallucinogens, though higher 'negative effects while high' and greater 'value for money' were reported. The most common (41.7%) drug source was via a website. The NBOMe drugs have emerged recently, are frequently bought using the internet and have similar effects to other hallucinogenic drugs; however, they may pose larger risks, due to the limited knowledge about them, their relatively low price and availability via the internet.
N-苄基苯乙胺类化合物是一类新型致幻药物，是5-羟色胺2A受体的强效激动剂，人类使用历史较短，在大多数国家都可以在网上买到。在本研究中，我们试图调查其使用模式、使用者特征及自我报告的效果。2012年开展了一项探索药物使用模式的横断面匿名在线调查（n = 22289），包括有关25B-N-苄基苯乙胺、25C-N-苄基苯乙胺和25I-N-苄基苯乙胺以及对照药物使用情况的问题。我们发现，2.6%的受访者（n = 582）报告曾尝试过三种N-苄基苯乙胺类药物中的一种，其中25I-N-苄基苯乙胺最受欢迎，占2.0%（n = 442）。几乎所有（93.5%）最后尝试的新药为N-苄基苯乙胺类药物的受访者都是在2012年尝试的，该组中81.2%的人通过口服或舌下/口腔颊部给药。主观效果与对照血清素能致幻剂相似，不过报告称“嗨的时候负面影响更大”以及“性价比更高”。最常见的（41.7%）药物来源是通过网站。N-苄基苯乙胺类药物最近才出现，经常通过互联网购买，与其他致幻药物效果相似；然而，由于对它们的了解有限、价格相对较低且可通过互联网获取，它们可能带来更大的风险。
