Stefenelli T, Kuzmits R, Ulrich W, Glogar D
Department of Cardiology, University of Vienna, Austria.
Eur Heart J. 1988 May;9(5):552-6. doi: 10.1093/oxfordjournals.eurheartj.a062542.
Twenty-one consecutive patients with testicular cancer treated with bleomycin, vinblastine, and cisplatin (PVB) were evaluated for acute vascular ischaemic events during chemotherapy. Angina pectoris occurred in 8/21 (38%) patients, a median 5.6 weeks after initiation of chemotherapy and persisted for 2-7 days. Raynaud's phenomenon was detected in seven (33%) subjects, transient ischaemia of the toes was found in six (29%) patients, one patient complained of migraine, but none had major cerebrovascular accidents. Patients with and without angina pectoris and/or Raynaud's phenomenon did not differ in respect of age, histology of tumor or medication. Ischaemia occurred at any time during the course of chemotherapy. No correlation was found between dosage of drugs and time of onset of ischaemic reactions. However, arterial occlusive event is a frequent and common toxicity and a result of treatment with PVB.
对连续21例接受博来霉素、长春碱和顺铂（PVB）治疗的睾丸癌患者在化疗期间的急性血管缺血事件进行了评估。8/21（38%）的患者出现心绞痛，化疗开始后中位5.6周出现，持续2 - 7天。7名（33%）受试者检测到雷诺现象，6名（29%）患者发现脚趾短暂缺血，1名患者主诉偏头痛，但无一例发生重大脑血管意外。有或无心绞痛和/或雷诺现象的患者在年龄、肿瘤组织学或用药方面无差异。缺血发生在化疗过程中的任何时间。未发现药物剂量与缺血反应发作时间之间存在相关性。然而，动脉闭塞事件是一种常见的毒性反应，是PVB治疗的结果。
