Wong L, Brun J L
Department of Obstetrics and Gynecology University Hospital Pellegrin, Bordeaux, France -
Minerva Ginecol. 2014 Feb;66(1):35-47.
Uterine fibroids are the commonest benign tumor of the female genital tract. They affect a significant proportion of reproductive aged women and while some women are asymptomatic, fibroids can cause excessive menstrual bleeding, pelvic pressure, and adversely affect reproductive outcomes. Myomectomy is the most suitable surgical option for women who desire preservation of their fertility potential. However, only a selected group of women of childbearing age will benefit from a myomectomy. Furthermore, the consequences of myomectomy on reproductive function have remained controversial. The purpose of this paper is to review the main surgical approaches for myomectomy - hysteroscopic resection, laparoscopic myomectomy and open myomectomy (by laparotomy) - and discuss evidence-based indications for myomectomy in women with fibroids, especially with regards to its impact on reproductive outcomes. A critical review of the literature pertaining to the surgical approaches of myomectomy and the indications for myomectomy was performed, focusing on their impact on fertility and reproductive outcomes. Myomectomy is useful for the treatment of symptomatic fibroids and in selected women with infertility. Symptomatic submucosal fibroids are classically treated by hysteroscopic resection. Symptomatic intramural and subserosal fibroids may be treated by myomectomy, either by laparotomy or laparoscopy depending on their number and size. Prophylactic myomectomy is not recommended for preventing obstetrical complications or the risk of leiomyosarcoma. Although fibroids can have a negative effect on fertility, only the removal of submucosal fibroids has been consistently shown to improve spontaneous fertility or outcomes of assisted reproduction technology.
子宫肌瘤是女性生殖道最常见的良性肿瘤。它们影响着相当比例的育龄妇女,虽然一些女性没有症状,但肌瘤可导致月经过多、盆腔压迫,并对生殖结局产生不利影响。肌瘤切除术是希望保留生育潜力的女性最合适的手术选择。然而,只有特定的育龄女性群体能从肌瘤切除术中获益。此外,肌瘤切除术对生殖功能的影响一直存在争议。本文旨在综述肌瘤切除术的主要手术方式——宫腔镜切除术、腹腔镜肌瘤切除术和开腹肌瘤切除术(通过剖腹术)——并讨论子宫肌瘤女性肌瘤切除术的循证指征,尤其是其对生殖结局的影响。对有关肌瘤切除术的手术方式和肌瘤切除术指征的文献进行了批判性综述,重点关注它们对生育能力和生殖结局的影响。肌瘤切除术可用于治疗有症状的肌瘤以及部分不孕女性。有症状的黏膜下肌瘤通常采用宫腔镜切除术治疗。有症状的肌壁间肌瘤和浆膜下肌瘤可根据其数量和大小,通过剖腹术或腹腔镜进行肌瘤切除术。不建议进行预防性肌瘤切除术以预防产科并发症或平滑肌肉瘤风险。虽然肌瘤可对生育能力产生负面影响,但一直以来只有切除黏膜下肌瘤能持续改善自然受孕能力或辅助生殖技术的结局。