Complementary addressed modification of nucleic acids with the alkylating derivatives of oligothymidylate ethyl phosphotriesters. Effect of the phosphotriester fragments' configuration. - Suppr | 超能文献

Complementary addressed modification of nucleic acids with the alkylating derivatives of oligothymidylate ethyl phosphotriesters. Effect of the phosphotriester fragments' configuration.

作者信息

Abramova T V, Vlassov V V, Lebedev A V, Ryte A S

机构信息

Institute of Bioorganic Chemistry, Siberian Division, USSR Academy of Sciences, Novosibirsk.

出版信息

FEBS Lett. 1988 Aug 15;236(1):243-5. doi: 10.1016/0014-5793(88)80323-5.

DOI:10.1016/0014-5793(88)80323-5

Abstract

The alkylating derivatives of four individual diastereomers of the oligonucleotide [dTp(Et)]3dTpU and two individual diastereomers of oligonucleotide [dTp(Et)dTp]4 have been synthesized. The reagents with the phosphorus atoms in the enantiomeric p" configuration are shown to be more efficient in reacting with poly(dA) and with nucleic acids in Krebs-2 ascites carcinoma cells compared to those with the phosphorus atoms in the p' configuration.

摘要

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