Gurumurthy Prema, Borra Sai Krishna, Yeruva Rama Krishna Reddy, Babu Sai, Thomas Joy, Cherian Kotturathu Mammen
Department of Biochemistry, Frontier Lifeline Hospital and Dr KM Cherian Heart Foundation, Chennai, Tamilnadu, India.
Asian Cardiovasc Thorac Ann. 2013 Aug;21(4):426-31. doi: 10.1177/0218492312458511. Epub 2013 Jul 1.
The aim of our study was to determine neopterin levels in patients with acute coronary syndrome, in which the release of various cytokines activates the cellular immune system. There is an increase in the number and activity of T-cells in unstable atherosclerotic plaques, and of type 1 helper T-cells that produce interferon γ, which in turn produces neopterin, a byproduct of the guanosine triphosphate-biopterin pathway and a marker for activated macrophages.
We studied 600 subjects consisting of healthy volunteers and patients with noncardiac chest pain, ST-segment elevation myocardial infarction, non-ST-segment elevation myocardial infarction, or unstable angina. Neopterin levels were determined by high-performance liquid chromatography.
Mean serum neopterin levels in ST-segment elevation myocardial infarction (11.5 ± 3.2 nmol·L(-1)), non-ST-segment elevation myocardial infarction (9.8 ± 2.9 nmol·L(-1)), and unstable angina patients (9.4 ± 2.3 nmol·L(-1)) were significantly higher than those in noncardiac chest pain patients (7.4 ± 1.9 nmol·L(-1)) and healthy volunteers (7.2 ± 0.6 nmol·L(-1); p < 0.001).
These findings suggest that serum neopterin levels may be a useful marker of systemic inflammation, and measurement of serum neopterin may be helpful in assessing the risk of developing coronary heart disease.
我们研究的目的是测定急性冠状动脉综合征患者的蝶呤水平，在该综合征中，多种细胞因子的释放会激活细胞免疫系统。不稳定动脉粥样硬化斑块中的T细胞数量和活性增加，产生干扰素γ的1型辅助性T细胞数量和活性也增加，而干扰素γ反过来会产生蝶呤，蝶呤是三磷酸鸟苷 - 生物蝶呤途径的副产物，也是活化巨噬细胞的标志物。
我们研究了600名受试者，包括健康志愿者以及患有非心源性胸痛、ST段抬高型心肌梗死、非ST段抬高型心肌梗死或不稳定型心绞痛的患者。通过高效液相色谱法测定蝶呤水平。
ST段抬高型心肌梗死患者（11.5±3.2 nmol·L⁻¹）、非ST段抬高型心肌梗死患者（9.8±2.9 nmol·L⁻¹）和不稳定型心绞痛患者（9.4±2.3 nmol·L⁻¹）的血清蝶呤平均水平显著高于非心源性胸痛患者（7.4±1.9 nmol·L⁻¹）和健康志愿者（7.2±0.6 nmol·L⁻¹；p<0.001）。
这些发现表明血清蝶呤水平可能是全身炎症的有用标志物，测定血清蝶呤可能有助于评估患冠心病的风险。
