Toussi Mehdi Seilanian, Bagheri Reza, Dayani Mahdieh, Anvari Kazem, Sheibani Shima
Cancer Research Center, Omid Hospital, Mashhad, Iran.
Asian Cardiovasc Thorac Ann. 2013 Aug;21(4):437-42. doi: 10.1177/0218492312462710. Epub 2013 Jul 9.
For patients with lung metastases from soft-tissue sarcoma, pulmonary metastasectomy is considered to be the only chance of possible cure. In this survey, we analyzed some potential prognostic factors affecting the outcome in these patients.
34 patients who underwent pulmonary metastasectomy for soft-tissue sarcoma from April 1996 to April 2007, were enrolled in our study. The median follow-up period was 26 months. Survival curves, factors affecting the outcome, and treatment success rate were evaluated.
Complete resection was achieved in 88.2% of patients. There was no perioperative mortality. The median overall survival and median disease-free survival were 42 and 27 months, respectively. Incomplete resection and bilateral lung metastases had significant adverse effects on overall survival. Shorter disease-free interval (<18 months) was a significant predictor of survival on multivariate analysis. Metastasectomy was attempted in 12 cases of whom 50% remained disease-free to the end of follow-up.
Complete resection is the most important defining factor of success rate and survival. Patients with bilateral lung metastases or a shorter disease-free interval have significantly lower success rates. Repeat metastasectomy is curative in many patients.
对于软组织肉瘤肺转移患者，肺转移瘤切除术被认为是可能治愈的唯一机会。在本研究中，我们分析了一些影响这些患者预后的潜在因素。
1996年4月至2007年4月期间接受软组织肉瘤肺转移瘤切除术的34例患者纳入本研究。中位随访期为26个月。评估生存曲线、影响预后的因素及治疗成功率。
88.2%的患者实现了完整切除。无围手术期死亡。中位总生存期和中位无病生存期分别为42个月和27个月。不完全切除和双侧肺转移对总生存期有显著不良影响。多因素分析显示，较短的无病间期（<18个月）是生存的显著预测因素。12例患者尝试了再次转移瘤切除术，其中50%至随访结束时仍无疾病复发。
完整切除是成功率和生存率的最重要决定性因素。双侧肺转移或无病间期较短的患者成功率显著较低。许多患者再次转移瘤切除术可治愈。
