Katona Cornelius L, Katona Cara P
Division of Psychiatry, University College London, London, UK.
North Central London Psychiatry Training Programme, London, UK.
Neuropsychiatr Dis Treat. 2014 Feb 19;10:349-54. doi: 10.2147/NDT.S39544. eCollection 2014.
Vortioxetine is a novel antidepressant with effects on multiple 5-HT receptors and on the serotonin transporter. This paper reviews preclinical and clinical evidence regarding its mechanism of action, its tolerability, and its efficacy in treating major depression. Clinical studies indicate that vortioxetine is effective in the treatment of major depression, though there is no suggestion of superiority over active comparators. There may be a clinically meaningful advantage in terms of tolerability.
伏硫西汀是一种新型抗抑郁药，对多种5-羟色胺（5-HT）受体和5-羟色胺转运体均有作用。本文综述了关于其作用机制、耐受性及治疗重度抑郁症疗效的临床前和临床证据。临床研究表明，伏硫西汀对治疗重度抑郁症有效，不过并无证据表明其优于活性对照药。在耐受性方面可能具有临床意义上的优势。
