发展了一种 2-叠氮芳基硼酸频哪醇酯与乙烯基三氟甲磺酸酯的铃木交叉偶联反应，以实现[2,3]-稠合吲哚杂环的合成。
Development of a Suzuki cross-coupling reaction between 2-azidoarylboronic pinacolate esters and vinyl triflates to enable the synthesis of [2,3]-fused indole heterocycles.
机构信息
Department of Chemistry, University of Illinois at Chicago , 845 West Taylor Street, Chicago, Illinois 60607, United States.
出版信息
J Org Chem. 2014 Mar 21;79(6):2781-91. doi: 10.1021/jo500252e. Epub 2014 Mar 12.
Abstract
The scope and limitations of a Suzuki reaction between 2-azidoarylboronic acid pinacolate esters and vinyl triflates are reported. This cross-coupling reaction enables the regioselective synthesis of indoles after a subsequent Rh(II)2-catalyzed sp(2)-C-H bond amination reaction.
摘要
报道了 2-叠氮芳基硼酸频哪醇酯和乙烯基三氟甲磺酸酯之间的铃木反应的范围和局限性。该交叉偶联反应在随后的 Rh(II)2 催化的 sp(2)-C-H 键氨化反应后，能够实现吲哚的区域选择性合成。
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