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一种用于C(sp(2))-对甲苯磺酸酯和甲磺酸酯的铃木-宫浦交叉偶联反应的多功能催化剂体系。

A versatile catalyst system for Suzuki-Miyaura cross-coupling reactions of C(sp(2))-tosylates and mesylates.

作者信息

Bhayana Brijesh, Fors Brett P, Buchwald Stephen L

机构信息

Department of Chemistry, Massachusetts Institute of Technology, Cambridge, Massachusetts 02139, USA.

出版信息

Org Lett. 2009 Sep 3;11(17):3954-7. doi: 10.1021/ol9015892.

DOI:10.1021/ol9015892
PMID:19663467
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC2759755/
Abstract

A catalyst system for the Suzuki-Miyaura cross-coupling reactions of aryl and vinyl tosylates and mesylates has been developed. This catalyst displays excellent functional group tolerance and allows the coupling of heteroarylboronic acids with aryl tosylates and mesylates to be performed in high yields. Moreover, reactions employing alkylboronic acids, as well as heteroaryl, vinyl, and allylic pinacol boronate esters, were conducted with high efficiencies.

摘要

已开发出一种用于芳基和乙烯基甲苯磺酸酯及甲磺酸酯的铃木-宫浦交叉偶联反应的催化体系。该催化剂表现出优异的官能团耐受性，能使杂芳基硼酸与芳基甲苯磺酸酯和甲磺酸酯的偶联反应高产率地进行。此外，使用烷基硼酸以及杂芳基、乙烯基和烯丙基频哪醇硼酸酯的反应也能高效进行。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/a5c4/2759755/0543a2a22063/nihms138099f3.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/a5c4/2759755/a0bdbcbf6ef6/nihms138099f1.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/a5c4/2759755/4a9b727d7994/nihms138099f2.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/a5c4/2759755/0543a2a22063/nihms138099f3.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/a5c4/2759755/a0bdbcbf6ef6/nihms138099f1.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/a5c4/2759755/4a9b727d7994/nihms138099f2.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/a5c4/2759755/0543a2a22063/nihms138099f3.jpg

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