Manton S L, Scully C
University Department of Oral Medicine, Surgery, and Pathology, Bristol Dental Hospital and School, England.
Oral Surg Oral Med Oral Pathol. 1988 Jul;66(1):37-40. doi: 10.1016/0030-4220(88)90063-1.
Vesiculobullous diseases, including mucous membrane pemphigoid (MMP), are uncommon. This study was a retrospective examination of the clinical findings, histopathologic findings, and lesional immunostaining with respect to 76 consecutive patients referred to the Department of Oral Medicine, Surgery and Pathology, Bristol Dental Hospital and School, between 1982 and 1985 with a potential diagnosis of MMP. Of these, 42 patients were assigned alternative clinical diagnoses, 71% of which were confirmed by immunostaining and histology. Thus, MMP was clinically diagnosed in 34 patients (28 women and 6 men, with an average age of 59 years). However, unequivocal histologic confirmation of this diagnosis was obtained for only 4 patients, and direct immunostaining confirmation was obtained for just 7 patients. On the basis of a combination of the clinical, histopathologic, and direct immunofluorescence examinations, in only 3 of the 34 patients (8%) was an unequivocal diagnosis of classic MMP possible.
包括黏膜类天疱疮（MMP）在内的水疱大疱性疾病并不常见。本研究对1982年至1985年间转诊至布里斯托尔牙科医院及学校口腔医学、外科和病理学系的76例疑似MMP患者的临床发现、组织病理学发现及皮损免疫染色进行了回顾性检查。其中，42例患者被诊断为其他临床疾病，其中71%经免疫染色和组织学证实。因此，临床诊断为MMP的患者有34例（28名女性和6名男性，平均年龄59岁）。然而，只有4例患者获得了明确的组织学诊断证实，仅有7例患者获得了直接免疫染色证实。基于临床、组织病理学和直接免疫荧光检查结果，34例患者中只有3例（8%）能够明确诊断为典型MMP。
