Antiphosphotyrosine recovery of phospholipase C activity after EGF treatment of A-431 cells.
作者信息
Wahl M I, Daniel T O, Carpenter G
机构信息
Department of Biochemistry, Vanderbilt University School of Medicine, Nashville, TN 37232.
出版信息
Science. 1988 Aug 19;241(4868):968-70. doi: 10.1126/science.2457254.
PMID:2457254
Abstract
A tenfold increase in phospholipase C activity specific for phosphatidylinositol 4,5-bisphosphate (PIP2) was immunopurified from extracts of A-431 epidermoid carcinoma cells stimulated with epidermal growth factor. This finding suggests a biochemical link between growth factor-stimulated tyrosine kinase activity and PIP2 hydrolysis.
摘要
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