Department of Biological Sciences, Border Biomedical Research Center, The University of Texas at El Paso, El Paso, TX, USA.
Adv Exp Med Biol. 2020;1131:215-242. doi: 10.1007/978-3-030-12457-1_9.
Phospholipase C (PLC) family members constitute a family of diverse enzymes. Thirteen different family members have been cloned. These family members have unique structures that mediate various functions. Although PLC family members all appear to signal through the bi-products of cleaving phospholipids, it is clear that each family member, and at times each isoform, contributes to unique cellular functions. This chapter provides a review of the current literature on PLC. In addition, references have been provided for more in-depth information regarding areas that are not discussed including tyrosine kinase activation of PLC. Understanding the roles of the individual PLC enzymes, and their distinct cellular functions, will lead to a better understanding of the physiological roles of these enzymes in the development of diseases and the maintenance of homeostasis.
磷脂酶 C（PLC）家族成员构成了一个多样化的酶家族。已经克隆了十三个不同的家族成员。这些家族成员具有独特的结构，介导各种功能。尽管 PLC 家族成员似乎都通过裂解磷脂的产物进行信号转导，但显然每个家族成员，有时甚至每个同工型，都为独特的细胞功能做出贡献。本章对目前关于 PLC 的文献进行了综述。此外，还提供了有关未讨论的领域（包括 PLC 的酪氨酸激酶激活）的更深入信息的参考文献。了解单个 PLC 酶的作用及其独特的细胞功能将有助于更好地理解这些酶在疾病发展和内稳态维持中的生理作用。
