磷脂酶 C
Phospholipase C.
机构信息
Department of Biological Sciences, Border Biomedical Research Center, The University of Texas at El Paso, El Paso, TX, USA.
出版信息
Adv Exp Med Biol. 2020;1131:215-242. doi: 10.1007/978-3-030-12457-1_9.
Abstract
Phospholipase C (PLC) family members constitute a family of diverse enzymes. Thirteen different family members have been cloned. These family members have unique structures that mediate various functions. Although PLC family members all appear to signal through the bi-products of cleaving phospholipids, it is clear that each family member, and at times each isoform, contributes to unique cellular functions. This chapter provides a review of the current literature on PLC. In addition, references have been provided for more in-depth information regarding areas that are not discussed including tyrosine kinase activation of PLC. Understanding the roles of the individual PLC enzymes, and their distinct cellular functions, will lead to a better understanding of the physiological roles of these enzymes in the development of diseases and the maintenance of homeostasis.
摘要
磷脂酶 C（PLC）家族成员构成了一个多样化的酶家族。已经克隆了十三个不同的家族成员。这些家族成员具有独特的结构，介导各种功能。尽管 PLC 家族成员似乎都通过裂解磷脂的产物进行信号转导，但显然每个家族成员，有时甚至每个同工型，都为独特的细胞功能做出贡献。本章对目前关于 PLC 的文献进行了综述。此外，还提供了有关未讨论的领域（包括 PLC 的酪氨酸激酶激活）的更深入信息的参考文献。了解单个 PLC 酶的作用及其独特的细胞功能将有助于更好地理解这些酶在疾病发展和内稳态维持中的生理作用。
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本文引用的文献
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Phospholipase C delta 4 (PLCδ4) is a nuclear protein involved in cell proliferation and senescence in mesenchymal stromal stem cells.磷酸酶 PLCδ4 是一种核蛋白，参与间充质基质干细胞的增殖和衰老。
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G protein βγ subunits directly interact with and activate phospholipase Cϵ.G 蛋白 βγ 亚基直接与磷脂酶 Cε相互作用并使其激活。
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PLCγ1: Potential arbitrator of cancer progression.磷脂酶Cγ1：癌症进展的潜在仲裁者。
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Phospholipase C zeta and calcium oscillations at fertilisation: The evidence, applications, and further questions.受精时的磷脂酶Cζ与钙振荡：证据、应用及更多问题
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Increased intracellular Ca concentrations prevent membrane localization of PH domains through the formation of Ca-phosphoinositides.细胞内钙离子浓度的增加通过形成钙-磷酰肌醇阻止 PH 结构域的膜定位。
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