Grundmann Oliver, Yoon Saunjoo L
Oliver Grundmann, Department of Medicinal Chemistry, College of Pharmacy, University of Florida, FL 32610, United States.
World J Gastroenterol. 2014 Jan 14;20(2):346-62. doi: 10.3748/wjg.v20.i2.346.
Irritable bowel syndrome (IBS) is a common gastrointestinal disorder with a high incidence in the general population. The diagnosis of IBS is mainly based on exclusion of other intestinal conditions through the absence of inflammatory markers and specific antigens. The current pharmacological treatment approaches available focus on reducing symptom severity while often limiting quality of life because of significant side effects. This has led to an effectiveness gap for IBS patients that seek further relief to increase their quality of life. Complementary and alternative medicines (CAM) have been associated with a higher degree of symptom management and quality of life in IBS patients. Over the past decade, a number of important clinical trials have shown that specific herbal therapies (peppermint oil and Iberogast(®)), hypnotherapy, cognitive behavior therapy, acupuncture, and yoga present with improved treatment outcomes in IBS patients. We propose an integrative approach to treating the diverse symptoms of IBS by combining the benefits of and need for pharmacotherapy with known CAM therapies to provide IBS patients with the best treatment outcome achievable. Initial steps in this direction are already being considered with an increasing number of practitioners recommending CAM therapies to their patients if pharmacotherapy alone does not alleviate symptoms sufficiently.
肠易激综合征(IBS)是一种常见的胃肠道疾病,在普通人群中发病率较高。IBS的诊断主要基于通过缺乏炎症标志物和特定抗原来排除其他肠道疾病。目前可用的药物治疗方法侧重于减轻症状严重程度,但由于显著的副作用,往往会限制生活质量。这导致寻求进一步缓解以提高生活质量的IBS患者存在疗效差距。补充和替代医学(CAM)与IBS患者更高程度的症状管理和生活质量相关。在过去十年中,一些重要的临床试验表明,特定的草药疗法(薄荷油和伊比罗格斯(Iberogast®))、催眠疗法、认知行为疗法、针灸和瑜伽在IBS患者中呈现出改善的治疗效果。我们建议采用一种综合方法来治疗IBS的各种症状,将药物治疗的益处和需求与已知的CAM疗法相结合,为IBS患者提供可实现的最佳治疗效果。随着越来越多的从业者建议,如果单独的药物治疗不能充分缓解症状,就向患者推荐CAM疗法,已经在朝着这个方向迈出了初步的步伐。