Myers Charles E, Gatalica Zoran, Spinelli Anthony, Castro Michael, Linden Erica, Sartor Oliver, Sargent Mathew
Foundation for Cancer Research and Education, Earlysville, Va., USA.
Caris Life Sciences, Phoenix, Ariz., USA.
Case Rep Oncol. 2014 Jan 16;7(1):52-7. doi: 10.1159/000357972. eCollection 2014 Jan.
Cancer of Cowper's gland is a very rare cancer. This case represents the 9th case in the medical literature. As such, there are no phase II or phase III trials to guide treatment. In this article, we report the successful treatment of a patient over a 7-year period guided solely by molecular profiling. Through multiple cycles to treatment, the cancer was controlled using drugs targeting c-kit, as the cancer steadily increased the expression of c-kit. This report also documents the use of a novel drug combination based on sunitinib that was well tolerated and may warrant testing in other c-kit-dependent cancers.
尿道球腺癌是一种极为罕见的癌症。该病例是医学文献中的第9例。因此，没有II期或III期试验来指导治疗。在本文中，我们报告了一名患者在仅由分子谱分析指导的7年期间的成功治疗情况。经过多个治疗周期，由于癌症不断增加c-kit的表达，使用靶向c-kit的药物控制了癌症。本报告还记录了一种基于舒尼替尼的新型药物组合的使用情况，该组合耐受性良好，可能值得在其他依赖c-kit的癌症中进行测试。
