原发性肝神经内分泌癌的术后结局：综述文章
Postoperative outcomes of primary hepatic neuroendocrine carcinomas: review article.
作者信息
Shinkawa Hiroji, Takatsuka Satoshi, Kaizaki Ryoji, Fujiwara Yushi, Kurai Osamu, Yamazaki Osamu
机构信息
Department of Surgery, Osaka City Juso General Hospital, Japan.
Department of Gastroenterological Medicine, Osaka City Juso General Hospital, Japan.
出版信息
Osaka City Med J. 2013 Dec;59(2):105-13.
BACKGROUND
We examined the course of a primary hepatic neuroendocrine carcinoma (PHNEC) patient and analyzed the postoperative outcome of all reported PHNEC cases.
METHODS
A literature search for PHNEC cases was performed using PubMed. All reported cases and our present patient were analyzed in this study. Survival analysis was performed using the Kaplan-Meier method. Risk factors for the recurrence of PHNEC following hepatic resection were investigated.
RESULTS
A total of 43 patients were analyzed in this study. The 3-, 5-, and 7-year overall survival rates were 55%, 48%, and 48%, respectively. The 3-, 5-, and 7-year overall survival rates in surgery patients were 78% each, and 25%, 17%, and 17%, respectively in nonsurgery patients. Lymph node metastasis posed a significant risk factor for postoperative recurrence.
CONCLUSIONS
Hepatic surgery is an appropriate therapeutic treatment for PHNEC without distant metastasis nor lymph node metastasis. Adjuvant chemotherapy might be necessary for PHNEC patients with lymph node metastases.
背景
我们研究了一名原发性肝神经内分泌癌（PHNEC）患者的病程，并分析了所有已报道的PHNEC病例的术后结果。
方法
使用PubMed对PHNEC病例进行文献检索。本研究分析了所有已报道的病例以及我们目前的患者。采用Kaplan-Meier方法进行生存分析。研究肝切除术后PHNEC复发的危险因素。
结果
本研究共分析了43例患者。3年、5年和7年总生存率分别为55%、48%和48%。手术患者的3年、5年和7年总生存率均为78%，非手术患者分别为25%、17%和17%。淋巴结转移是术后复发的重要危险因素。
结论
对于无远处转移和淋巴结转移的PHNEC，肝手术是一种合适的治疗方法。对于有淋巴结转移的PHNEC患者，可能需要辅助化疗。
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