Jerant Patić Vera, Milosević Vesna, Hrnjaković Cvjetković Ivana, Patić Aleksandra, Stefan Mikić Sandra, Ristić Marina
Institut zajavno zdravlje Vojvodine, Novi Sad.
Klinicki centar Vojvodine, Klinika za infektivne bolesti, Novi Sad.
Med Pregl. 2013 Nov-Dec;66(11-12):459-63. doi: 10.2298/mpns1312459j.
The aim of this study was to determine the percentage of seropositive pregnant women, i.e. of pregnant women infected with Toxoplasma gondii in order to provide an insight into the risk of developing congenital toxoplasmosis in our community.
In the period of two years, 662 pregnant women from Vojvodina were examined serologically. The enzyme-linked immunosorbent assay tests were performed to determine IgM and IgG antibodies against Toxoplasma gondii and the complement fixation test was done to detect total antibodies against Toxoplasma gondii.
Seropositivity was determined in 180 pregnant women (27.19%). Of 135 pregnant women examined in the routine control in pregnancy, 16.30% were seropositive and out of five proven, completely new Toxoplasma gondii intfections, three were detected in pregnant women who had undergone the routine check-up for no specific symptoms. A detailed analysis of the frequency of seropositive findings in relation to clinical diagnoses and the place of residence of pregnant women (urban and rural areas) was performed. At the same time, the results from the serological reactions were presented, commented and interpreted, and recommendations were given for the implementation of additional examinations (eg, IgG antibody avidity test) in order to make the accurate diagnosis.
It can be concluded that the occurrence of congenital toxoplasmosis is still a problem in our community and that the best prevention is the prompt and adequate examination of pregnant women for the presence of Toxoplasma gondii infection.
本研究的目的是确定血清反应阳性孕妇的比例，即感染弓形虫的孕妇比例，以便深入了解我们社区先天性弓形虫病的发病风险。
在两年时间里，对来自伏伊伏丁那的662名孕妇进行了血清学检查。采用酶联免疫吸附试验检测抗弓形虫IgM和IgG抗体，并进行补体结合试验以检测抗弓形虫总抗体。
180名孕妇（27.19%）血清反应呈阳性。在孕期常规检查的135名孕妇中，16.30%血清反应呈阳性，在5例经证实的全新弓形虫感染病例中，有3例是在无特定症状而接受常规检查的孕妇中检测到的。对血清反应阳性结果的频率与临床诊断以及孕妇居住地（城市和农村地区）进行了详细分析。同时，对血清学反应结果进行了呈现、评论和解读，并给出了实施额外检查（如IgG抗体亲和力试验）以进行准确诊断的建议。
可以得出结论，先天性弓形虫病的发生在我们社区仍然是一个问题，最好的预防措施是及时、充分地检查孕妇是否感染弓形虫。
