Rainey J M, Hill J B, Crowley J
Louisiana State University Medical Center, Lafayette.
Invest New Drugs. 1988 Apr;6(1):45-6. doi: 10.1007/BF00170779.
Fludarabine phosphate was given as a 5 day bolus infusion to eleven evaluable patients with recurrent small cell lung carcinoma. Patients had failed on one prior treatment regimen. There were no responses in the eleven evaluable patients. Severe neurologic toxicity occurred in one patient. Fludarabine phosphate as given in this protocol was not an effective agent in recurrent small cell lung carcinoma.
对11例可评估的复发性小细胞肺癌患者给予5天的氟达拉滨磷酸盐大剂量静脉输注。患者之前的一种治疗方案已失败。11例可评估患者均无反应。1例患者出现严重神经毒性。本方案中给予的氟达拉滨磷酸盐在复发性小细胞肺癌中不是一种有效的药物。
