肠道中的激素信号传递。
Hormonal signaling in the gut.
机构信息
Toronto General Research Institute, University Health Network, Toronto, Ontario M5G 1L7; Departments of Physiology, University of Toronto, Toronto, Ontario M5S 1A8.
Toronto General Research Institute, University Health Network, Toronto, Ontario M5G 1L7; Departments of Medicine, University of Toronto, Toronto, Ontario M5S 1A8.
出版信息
J Biol Chem. 2014 Apr 25;289(17):11642-11649. doi: 10.1074/jbc.O114.556068. Epub 2014 Feb 27.
Abstract
The gut is anatomically positioned to play a critical role in the regulation of metabolic homeostasis, providing negative feedback via nutrient sensing and local hormonal signaling. Gut hormones, such as cholecystokinin (CCK) and glucagon-like peptide-1 (GLP-1), are released following a meal and act on local receptors to regulate glycemia via a neuronal gut-brain axis. Additionally, jejunal nutrient sensing and leptin action are demonstrated to suppress glucose production, and both are required for the rapid antidiabetic effect of duodenal jejunal bypass surgery. Strategies aimed at targeting local gut hormonal signaling pathways may prove to be efficacious therapeutic options to improve glucose control in diabetes.
摘要
肠道在调节代谢稳态方面具有关键作用，通过营养感应和局部激素信号提供负反馈。餐后会释放胆囊收缩素（CCK）和胰高血糖素样肽-1（GLP-1）等肠道激素，这些激素通过神经元肠道-脑轴作用于局部受体，调节血糖。此外，空肠营养感应和瘦素作用被证明可以抑制葡萄糖生成，十二指肠空肠旁路手术的快速抗糖尿病作用也需要这两者。靶向肠道局部激素信号通路的策略可能被证明是改善糖尿病患者血糖控制的有效治疗选择。
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