雌激素受体1基因（TA）n多态性与男性孤立性心房颤动相关。

Estrogen receptor 1 gene (TA)n polymorphism is associated with lone atrial fibrillation in men.

作者信息

Golubić Karlo, Šmalcelj Anton, Sertić Jadranka, Juričić Ljiljana

机构信息

Karlo Golubic, Department of Cardiovascular Diseases, University Hospital Center, School of Medicine, University of Zagreb, Kispaticeva 12, 10000 Zagreb, Croatia,

出版信息

Croat Med J. 2014 Feb;55(1):38-44. doi: 10.3325/cmj.2014.55.38.

DOI:10.3325/cmj.2014.55.38

PMID:24577825

原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC3944416/

Abstract

AIM

To determine the association between the number of thymine-adenine (TA)n dinucleotide repeats in the promoter region of the gene coding for the estrogen receptor alpha (ESR1) and the prevalence of lone atrial fibrillation (AF) in men.

METHODS

We conducted a case-control study involving 89 men with lone AF and 166 healthy male controls. The ESR1 genotype was established by polymerase chain reaction and capillary electrophoresis. To assess the association of ESR1 genotype with AF, logistic regression models were built with AF as outcome.

RESULTS

Men with lone AF had significantly greater number of (TA)n repeats of single alleles than controls (mean ± standard deviation, 19.2 ± 4.2 vs 18 ± 4.3, P = 0.010). After adjustment for other factors, a unit-increase in (TA)n repeat number was associated with a significantly greater likelihood of AF (odds ratio 1.069; 95% confidence interval 1.024-1.116, P=0.002).

CONCLUSIONS

Our results indicate that a greater number of (TA)n repeats in the promoter region of ESR1 is associated with a significantly increased likelihood of lone atrial fibrillation in men.

摘要

目的

确定雌激素受体α（ESR1）编码基因启动子区域胸腺嘧啶 - 腺嘌呤（TA）n二核苷酸重复序列的数量与男性孤立性心房颤动（AF）患病率之间的关联。

方法

我们进行了一项病例对照研究，纳入89例男性孤立性AF患者和166例健康男性对照。通过聚合酶链反应和毛细管电泳确定ESR1基因型。为评估ESR1基因型与AF的关联，构建以AF为结局的逻辑回归模型。

结果

孤立性AF男性的单等位基因（TA）n重复序列数量显著多于对照组（均值±标准差，19.2±4.2对18±4.3，P = 0.010）。在对其他因素进行调整后，（TA）n重复序列数量每增加一个单位，AF发生的可能性显著增加（比值比1.069；95%置信区间1.024 - 1.116，P = 0.002）。