全基因组关联研究心房颤动：过去、现在和未来。
Genome-wide association studies of atrial fibrillation: past, present, and future.
机构信息
Department of Medicine I, University Hospital Munich, Campus Grosshadern, Marchioninistrasse 15, 81377 Munich, Germany.
出版信息
Cardiovasc Res. 2011 Mar 1;89(4):701-9. doi: 10.1093/cvr/cvr001. Epub 2011 Jan 18.
Abstract
Genome-wide association studies (GWAS) for atrial fibrillation (AF) have identified three distinct genetic loci on chromosomes 1q21, 4q25, and 16q22 that are associated with the arrhythmia. Susceptibility loci also have been identified by GWAS for PR interval duration, a quantitative phenotype related to AF. In this review article, we have sought to summarize the latest findings for population-based genetic studies of AF, to highlight ongoing functional studies, and to explore the future directions of genetic research on AF.
摘要
全基因组关联研究（GWAS）已经确定了三个不同的与心律失常相关的遗传位点，位于染色体 1q21、4q25 和 16q22。GWAS 还确定了 PR 间期持续时间的易感性位点，这是一种与房颤相关的定量表型。在这篇综述文章中，我们试图总结房颤的基于人群的遗传研究的最新发现，强调正在进行的功能研究，并探讨房颤遗传研究的未来方向。
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