Dinleyici Ener Cagri, Vandenplas Yvan
Pediatric Intensive Care and Infectious Disease Unit, Department of Pediatrics, Eskisehir Osmangazi University Faculty of Medicine, Eskisehir, Turkey.
Acta Paediatr. 2014 Jul;103(7):e300-5. doi: 10.1111/apa.12617. Epub 2014 Mar 24.
Guidelines consider certain probiotics useful in the management of acute gastroenteritis. This study evaluated the use of Lactobacillus (L) reuteri DSM 17938.
A multicentre, randomised, single-blind clinical trial was performed in hospitalised children with acute gastroenteritis lasting 12-72 h. Children received conventional therapy with, or without, 1 × 10(8) CFU of L. reuteri DSM 17938 for 5 days. The primary endpoint was the duration of diarrhoea and secondary outcomes were days of hospitalisation and the percentage of children with diarrhoea after each day of treatment.
We compared 64 children receiving L. reuteri with 63 controls. Lactobacillus reuteri reduced the duration of diarrhoea after 24 h (p < 0.001) and more diarrhoea-free children were seen in the L. reuteri than control group after 24 and 48 h (50% versus 5%, p < 0.001) and 72 h (69% versus 11%, p < 0.001). Lactobacillus reuteri reduced mean hospital stays (4.31 ± 1.3 days versus 5.46 ± 1.77 days, p < 0.001). Prolonged diarrhoea occurred in 17% of the controls, but none of the L. reuteri group. No adverse effects were reported.
Lactobacillus reuteri effectively reduced the duration of acute diarrhoea and hospital stays in children hospitalised with acute gastroenteritis. Outpatient data are now required.
指南认为某些益生菌对急性胃肠炎的治疗有益。本研究评估了罗伊氏乳杆菌DSM 17938的应用。
对住院12至72小时的急性胃肠炎患儿进行了一项多中心、随机、单盲临床试验。患儿接受常规治疗，部分患儿同时接受1×10⁸CFU罗伊氏乳杆菌DSM 17938治疗，疗程5天。主要终点为腹泻持续时间，次要结局为住院天数及治疗后每日腹泻患儿的百分比。
我们将64例接受罗伊氏乳杆菌治疗的患儿与63例对照组患儿进行了比较。罗伊氏乳杆菌可缩短24小时后的腹泻持续时间（p<0.001），在24小时和48小时后（50%对5%，p<0.001）以及72小时后（69%对11%，p<0.001），罗伊氏乳杆菌组腹泻停止的患儿比对照组更多。罗伊氏乳杆菌可缩短平均住院时间（4.31±1.3天对5.46±1.77天，p<0.001）。对照组17%的患儿出现了持续性腹泻，而罗伊氏乳杆菌组无此情况。未报告不良反应。
罗伊氏乳杆菌可有效缩短急性胃肠炎住院患儿的急性腹泻持续时间和住院时间。目前还需要门诊数据。
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