Zhu Yong, Hollis James H
Department of Food Science and Human Nutrition, Iowa State University , Ames, IA , USA.
Int J Food Sci Nutr. 2014 Aug;65(5):615-20. doi: 10.3109/09637486.2013.854747. Epub 2014 Mar 3.
The effect of body weight status on appetite, glycemic response and gastric emptying rate was investigated using a liquid meal. Lean and overweight males rated their subjective appetite with blood samples collected for measurement of glucose, biomarkers of appetite and gastric emptying rate for 3 h following consumption of the isocaloric test meal. Overweight participants had a higher rating on postprandial hunger (p < 0.001), preoccupation with food (p < 0.001) and desire to eat (p < 0.001), with fullness being lower (p = 0.001). Postprandial plasma concentration of cholecystokinin-33 was lower (p = 0.007) and total ghrelin was higher (p = 0.012) in overweight participants. A delayed gastric emptying rate was observed in lean participants. There was no difference in postprandial glycemic response (p = 0.189). These results suggest the postprandial appetite pattern was different between lean and overweight males when consuming an isocaloric meal. This may have implications for overweight individuals who attempt to lose weight through restricting food intake.
使用流食研究体重状况对食欲、血糖反应和胃排空率的影响。体型偏瘦和超重的男性在食用等热量测试餐后3小时,通过采集血样来测定血糖、食欲生物标志物和胃排空率,以此对他们的主观食欲进行评分。超重参与者餐后饥饿感评分更高(p < 0.001)、对食物的关注程度更高(p < 0.001)以及进食欲望更强(p < 0.001),而饱腹感更低(p = 0.001)。超重参与者餐后血浆中胆囊收缩素-33的浓度更低(p = 0.007),而总胃饥饿素更高(p = 0.012)。体型偏瘦的参与者观察到胃排空率延迟。餐后血糖反应没有差异(p = 0.189)。这些结果表明,体型偏瘦和超重的男性在食用等热量餐时,餐后食欲模式有所不同。这可能对试图通过限制食物摄入量来减肥的超重个体有影响。