三组分 Povarov 反应-杂芳构化：5,6-二氢吲哚并[1,2-a]喹啉的合成。
Three-component Povarov reaction-heteroannulation with arynes: synthesis of 5,6-dihydroindolo[1,2-a]quinolines.
机构信息
Laboratory of Synthesis and Natural Products, Institute of Chemical Sciences and Engineering, Ecole Polytechnique Fédérale de Lausanne , EPFL-SB-ISIC-LSPN, BCH 5304, 1015 Lausanne, Switzerland.
出版信息
Org Lett. 2014 Mar 21;16(6):1756-9. doi: 10.1021/ol500447r. Epub 2014 Feb 28.
PMID:24580123
Abstract
A reaction of 2-acyl substituted tetrahydroquinolines, prepared by Lewis acid-catalyzed three-component reaction of α-oxo aldehydes, anilines, and dienophiles, with in situ generated arynes afforded 5,6-dihydroindolo[1,2-a]quinolines in good to excellent yields.
摘要
2-酰基取代的四氢喹啉通过路易斯酸催化的α-氧代醛、苯胺和双烯体的三组分反应制备，然后与原位生成的芳炔反应，以良好至优异的收率得到 5,6-二氢吲哚并[1,2-a]喹啉。
Zotero 插件