Kew M C, Vincent C, Rossel M, Revillard J P
Department of Medicine, University of Witwatersrand, Johannesburg, South Africa.
Am J Med. 1988 Sep;85(3):327-30. doi: 10.1016/0002-9343(88)90581-5.
Elevated levels of secretory IgA (S-IgA) have been detected in serum samples from patients with liver diseases and neoplasia with liver metastasis. We undertook the current study in order to determine the concentrations of different forms of free secretory component (SC) in sera from patients with hepatocellular carcinoma.
The concentrations of SC, S-IgA, and secretory IgM (S-IgM) were quantified in the sera of 100 patients with hepatocellular carcinoma, and in 77 matched healthy control subjects by using an enzyme-linked immunosorbent assay.
Free SC serum levels exceeded the upper limits of control values in 82 percent of patients with hepatocellular carcinoma, S-IgA levels in 88 percent of them, and S-IgM levels in 32 percent. Free SC levels were positively correlated with S-IgA and S-IgM levels. They were weakly correlated with gamma-glutamyl transpeptidase activity, but not with alpha-fetoprotein, beta 2-microglobulin, albumin, or IgA serum concentrations, nor with alkaline phosphatase activity.
The data clearly demonstrate the elevation of serum free SC concentrations as a novel biologic alteration in hepatocellular carcinoma since free SC levels appear to be correlated neither with tumor markers (alpha-fetoprotein, beta 2-microglobulin) nor with biliary obstruction.
在患有肝脏疾病和伴有肝转移的肿瘤患者的血清样本中检测到分泌型IgA（S-IgA）水平升高。我们开展了本研究，以确定肝细胞癌患者血清中不同形式的游离分泌成分（SC）的浓度。
采用酶联免疫吸附测定法对100例肝细胞癌患者及77例匹配的健康对照者血清中的SC、S-IgA和分泌型IgM（S-IgM）浓度进行定量。
82%的肝细胞癌患者游离SC血清水平超过对照值上限，88%的患者S-IgA水平超过上限，32%的患者S-IgM水平超过上限。游离SC水平与S-IgA和S-IgM水平呈正相关。它们与γ-谷氨酰转肽酶活性呈弱相关，但与甲胎蛋白、β2-微球蛋白、白蛋白或IgA血清浓度以及碱性磷酸酶活性均无相关性。
数据清楚地表明血清游离SC浓度升高是肝细胞癌一种新的生物学改变，因为游离SC水平似乎既与肿瘤标志物（甲胎蛋白、β2-微球蛋白）无关，也与胆道梗阻无关。
