患有神经病变和抗髓鞘相关糖蛋白IgM M蛋白血症患者的治疗。
Treatment of patients with neuropathy and anti-MAG IgM M-proteins.
作者信息
Nobile-Orazio E, Baldini L, Barbieri S, Marmiroli P, Spagnol G, Francomano E, Scarlato G
机构信息
Institute of Clinical Neurology, University of Milan, Italy.
出版信息
Ann Neurol. 1988 Jul;24(1):93-7. doi: 10.1002/ana.410240118.
Five patients with neuropathy and IgM M-proteins that reacted with myelin-associated glycoprotein (MAG) were treated for 10 to 20 months with cytostatic agents. In 2 patients, a decrease in serum M-protein and in anti-MAG IgM levels coincided with a progressive improvement of neuropathy. No clinical improvement and no decrease of anti-MAG IgM were observed in the other patients. The close relationship between the decrease of anti-MAG M-proteins and clinical improvement in these patients supports the pathogenetic role of the M-protein in the neuropathy.
5例患有神经病变且免疫球蛋白M（IgM）与髓鞘相关糖蛋白（MAG）发生反应的患者接受了10至20个月的细胞毒性药物治疗。其中2例患者血清M蛋白和抗MAG IgM水平降低，同时神经病变逐渐改善。其他患者未观察到临床改善，抗MAG IgM也未降低。这些患者中抗MAG M蛋白降低与临床改善之间的密切关系支持了M蛋白在神经病变中的致病作用。
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