Mayer-da-Silva A, Poiares-Baptista A, Guerra Rodrigo F, Teresa-Lopes M
Department of Dermatology, University Medical School of Lisbon, Hospital de Santa Maria, Portugal.
Arch Pathol Lab Med. 1988 Sep;112(9):928-31.
Histochemical and routine light microscopic studies were performed in nodular skin lesions excised from one patient with juvenile hyaline fibromatosis. The lesions had different times of evolution. Recent lesions showed a high density of fibroblastlike cells embedded in an amorphous matrix of glycoproteins, hyaluronic acid, and small amounts of chondroitin sulfates A and C and of dermatan sulfate. The progressive enlargement of the lesions was due to an increase in the amount of intercellular matrix produced by the cells that progressively displayed a pattern of peripheral stratification. In the older lesions, the matrix was mainly composed by chondroitin sulfates A and C. We suggest that juvenile hyaline fibromatosis represents a disease of the connective tissue with progressive abnormal differentiation to chondroid tissue.
对一名患有青少年透明纤维瘤病患者切除的结节性皮肤病变进行了组织化学和常规光学显微镜研究。这些病变具有不同的演变时间。近期病变显示成纤维细胞样细胞密度高，嵌入糖蛋白、透明质酸以及少量硫酸软骨素A、C和硫酸皮肤素的无定形基质中。病变的逐渐增大是由于细胞产生的细胞间基质数量增加，这些细胞逐渐呈现外周分层模式。在较老的病变中，基质主要由硫酸软骨素A和C组成。我们认为青少年透明纤维瘤病代表一种结缔组织疾病，伴有向软骨样组织的进行性异常分化。
