Javadzadeh Yousef, Bairami Atashgah Rahimeh, Barzegar-Jalali Mohammad, Soleimani Farshad, Mohammadi Ghobad, Sabzevari Araz, Adibkia Khosro
Drug Applied Research Center and Faculty of Pharmacy, Tabriz University of Medical Sciences, Tabriz, Iran.
Student Research Committee and Faculty of Pharmacy, Tabriz University of Medical Sciences, Tabriz, Iran.
Colloids Surf B Biointerfaces. 2014 Apr 1;116:751-6. doi: 10.1016/j.colsurfb.2014.01.050. Epub 2014 Feb 6.
The mesoporous glass-ceramic (GC) was employed as a carrier to investigate its capability for pharmaceutical applications. Piroxicam (PX) as a model drug was loaded in the GC by using of solvent evaporation technique. The physicochemical properties and morphology of the powders were evaluated employing X-ray powder diffractometry (XRPD), differential scanning calorimetry (DSC), Fourier-transform infrared spectroscopy (FT-IR), and scanning electron microscopy (SEM). The drug adsorption isotherms were assessed as well. Drug release profiles were examined by fitting the data to the 10 common kinetic models. The specific surface area, Vm (the volume of the N2 adsorbed on the 1g of the GC when the monolayer is complete) and the average pore diameter of the GC powder before and after loading process were measured by the Brunauer-Emmett-Teller (BET) and Barrett-Joyner-Halenda (BJH) analysis benefiting N2 adsorption/desorption isotherms. The ideal loading of PX in the GC was 41.8%. The average pore diameter for the GC was determined to be about 10nm. The Freundlich model was found to be the best adsorption isotherm. Decrease of the GC specific surface area and Vm values were observed after loading process. Drug release data were best fitted to the Weibull model with the shape factor of 0.4-0.7 signifying the Fickian diffusion of PX from the GC. Accordingly, the GC could be considered as a suitable adsorbent to develop an oral drug delivery system.
采用介孔微晶玻璃（GC）作为载体，研究其在药物应用方面的性能。以吡罗昔康（PX）作为模型药物，采用溶剂蒸发技术将其载入GC中。采用X射线粉末衍射法（XRPD）、差示扫描量热法（DSC）、傅里叶变换红外光谱法（FT-IR）和扫描电子显微镜（SEM）对粉末的物理化学性质和形态进行了评估。还评估了药物吸附等温线。通过将数据拟合到10种常见的动力学模型来研究药物释放曲线。利用N2吸附/脱附等温线，通过布鲁诺尔-埃米特-特勒（BET）和巴雷特-乔伊纳-哈伦达（BJH）分析测量了载入过程前后GC粉末的比表面积、Vm（单层完全形成时1g GC上吸附的N2体积）和平均孔径。PX在GC中的理想载入量为41.8%。GC的平均孔径约为10nm。发现弗伦德利希模型是最佳的吸附等温线。载入过程后观察到GC比表面积和Vm值降低。药物释放数据最适合威布尔模型，形状因子为0.4-0.7，表明PX从GC中的菲克扩散。因此，GC可被认为是开发口服给药系统的合适吸附剂。
