Investigation on the synthesis of 25-hydroxycholesterol.

作者信息

Zhao Qian, Ji Li, Qian Guo-Ping, Liu Jian-Gang, Wang Zi-Qiang, Yu Wan-Feng, Chen Xin-Zhi

机构信息

Key Laboratory of Biomass Chemical Engineering of Ministry of Education, Zhejiang University, Hangzhou 310027, PR China.

Zhejiang Garden Biochemical High-tech. Co., Ltd, Hangzhou 310018, PR China.

出版信息

Steroids. 2014 Jul;85:1-5. doi: 10.1016/j.steroids.2014.02.002. Epub 2014 Feb 28.

DOI:10.1016/j.steroids.2014.02.002

PMID:24582707

Abstract

A very efficient and environmentally benign method has been developed for the synthesis of 25-hydroxycholesterol. The reaction was performed in THF-water (4:1, v/v) using NBS as the brominating agent, followed by the easy reduction of C-Br with lithium aluminum hydride in THF, to yield the final product corresponding to a Markovnikov's rule. Excellent yields and regioselectivity have been obtained.

摘要