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年轻患者小脑出血的一个不常见病因:特发性血小板增多症。

An unusual cause of cerebellar hemorrhage in a young patient: essential thrombocythemia.

机构信息

Department of Neurology, Royal North Shore Hospital, Sydney, Australia; Department of Medicine, University of Sydney, Sydney, Australia.

Department of Neurology, Royal North Shore Hospital, Sydney, Australia.

出版信息

J Stroke Cerebrovasc Dis. 2014 May-Jun;23(5):e373-4. doi: 10.1016/j.jstrokecerebrovasdis.2013.12.013. Epub 2014 Feb 28.

Abstract

Essential thrombocythemia (ET) is a risk factor for ischemic stroke and, far more rarely, hemorrhage. We report the case of an untreated 32-year-old woman with a history of JAK2 V617F-positive ET with cerebellar and subarachnoid hemorrhages without evidence of sinus vein thrombosis. She was commenced on oral cytotoxic and antiplatelet therapy. This case report discusses the underlying mechanism of hemorrhagic thrombocythemia and the management dilemma presented by the recommended treatment implications.

摘要

原发性血小板增多症(ET)是缺血性中风的危险因素,且极罕见情况下会导致出血。我们报告了一例未经治疗的 32 岁 JAK2 V617F 阳性 ET 女性患者,其发生小脑和蛛网膜下腔出血,但无静脉窦血栓形成的证据。她开始接受口服细胞毒性和抗血小板治疗。本病例报告讨论了出血性血小板增多症的潜在机制,以及推荐治疗方案所带来的管理困境。

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