人类中的碱性肌球蛋白轻链由一个多基因家族编码，该家族包括成人骨骼肌、胚胎或心房以及非肌节亚型。
Alkali myosin light chains in man are encoded by a multigene family that includes the adult skeletal muscle, the embryonic or atrial, and nonsarcomeric isoforms.
作者信息
Seidel U, Bober E, Winter B, Lenz S, Lohse P, Goedde H W, Grzeschik K H, Arnold H H
机构信息
Department of Toxicology, Medical School, University of Hamburg, F.R.G.
出版信息
Gene. 1988 Jun 15;66(1):135-46. doi: 10.1016/0378-1119(88)90231-4.
A set of cDNA clones coding for alkali myosin light chains (AMLC) was isolated from fetal human skeletal muscle. Nucleotide sequence analysis and RNA expression patterns of individual clones revealed related sequences corresponding to (i) fast fiber type MLC1 and MLC3; (ii) the embryonic MLC that is also expressed in fetal ventricle and adult atrium (MLCemb); and (iii) a nonsarcomeric MLC isoform that is found in all nonmuscle cell types and smooth muscle. The AMLC gene family in man comprises unique copies for MLC1, MLC3 and MLCemb, and multiple copies for the nonsarcomeric MLC genes. The gene coding for MLC1 and MLC3 is located on human chromosome 2.
从胎儿人类骨骼肌中分离出一组编码碱性肌球蛋白轻链（AMLC）的cDNA克隆。对各个克隆进行核苷酸序列分析和RNA表达模式分析，发现了与之相关的序列，分别对应于：（i）快肌纤维型MLC1和MLC3；（ii）在胎儿心室和成人心房中也有表达的胚胎型MLC（MLCemb）；以及（iii）在所有非肌肉细胞类型和平滑肌中都存在的非肌节MLC异构体。人类的AMLC基因家族包括MLC1、MLC3和MLCemb的独特拷贝，以及非肌节MLC基因的多个拷贝。编码MLC1和MLC3的基因位于人类2号染色体上。
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