中国西南地区儿童尿白蛋白/肌酐比值的年龄和性别特异性参考值
Age- and gender-specific reference values for urine albumin/creatinine ratio in children of southwest China.
作者信息
Wu DaoQi, Yang HaiPing, Luo Juan, Zhang GaoFu, Li ShaoJun, Wang Mo, Tang XueHei, Wang Zhitie, Xu ZhenE, Li Qiu
机构信息
Department of Nephroimmunology, Key Laboratory of the Ministry of Education, Children's Hospital of Chongqing Medical University, Chongqing, China.
Chongqing Ninth People's Hospital, Chongqing, China.
出版信息
Clin Chim Acta. 2014 Apr 20;431:239-43. doi: 10.1016/j.cca.2014.02.015. Epub 2014 Feb 26.
BACKGROUND
The reference value for the urine albumin/creatinine ratio (ACR) varies between races and has not been previously validated in children. We assessed the ACR reference values and the factors that affect them in a population of healthy Chinese children.
METHODS
A total of 1986 healthy children (1078 males, 908 females) aged 6-19 y were enrolled. The 95th percentile of ACR was used as the normal upper limit. The associations between ACR and gender, age, body mass index (BMI), systolic blood pressure (SBP), preterm birth, intake of fruits, smoking, and geographical area were examined.
RESULTS
The normal upper limit of ACR was 14.7 mg/g for male children and 19.8 mg/g for female children. The ACR value for girls was significantly higher than that for boys (P<0.001). ACR was inversely correlated with age (P<0.001) and positively correlated with BMI, SBP, and smoking (all P<0.01).
CONCLUSIONS
The ACR reference value for healthy children in southwest China is approximately the same as the value for adults, but lower than that for the Western population. Age, SBP, BMI, and smoking in children influence ACR.
背景
尿白蛋白/肌酐比值（ACR）的参考值因种族而异，且此前未在儿童中得到验证。我们评估了中国健康儿童群体的ACR参考值及其影响因素。
方法
共纳入了1986名6至19岁的健康儿童（男1078名，女908名）。ACR的第95百分位数被用作正常上限。研究了ACR与性别、年龄、体重指数（BMI）、收缩压（SBP）、早产、水果摄入量、吸烟及地理区域之间的关联。
结果
男童ACR的正常上限为14.7mg/g，女童为19.8mg/g。女童的ACR值显著高于男童（P<0.001）。ACR与年龄呈负相关（P<0.001），与BMI、SBP和吸烟呈正相关（均P<0.01）。
结论
中国西南部健康儿童的ACR参考值与成人的参考值大致相同，但低于西方人群。儿童的年龄、SBP、BMI和吸烟会影响ACR。
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