Kim Deok Ryun, Ali Mohammad, Thiem Vu Dinh, Wierzba Thomas F
International Vaccine Institute, SNU Research Park, Nakseongdae-dong, Gwanak-gu, Seoul, Korea.
International Vaccine Institute, SNU Research Park, Nakseongdae-dong, Gwanak-gu, Seoul, Korea ; Johns Hopkins Bloomberg School of Public Health, Baltimore, Maryland, United States of America.
PLoS One. 2014 Feb 26;9(2):e89780. doi: 10.1371/journal.pone.0089780. eCollection 2014.
Hierarchical spatial models enable the geographic and ecological analysis of health data thereby providing useful information for designing effective health interventions. In this study, we used a Bayesian hierarchical spatial model to evaluate mortality data in Vietnam. The model enabled identification of socio-ecological risk factors and generation of risk maps to better understand the causes and geographic implications of prime-age (15 to less than 45 years) adult death.
The study was conducted in two sites: Nha Trang and Hue in Vietnam. The study areas were split into 500×500 meter cells to define neighborhoods. We first extracted socio-demographic data from population databases of the two sites, and then aggregated the data by neighborhood. We used spatial hierarchical model that borrows strength from neighbors for evaluating risk factors and for creating spatially smoothed risk map after adjusting for neighborhood level covariates. The Markov chain Monte Carlo procedure was used to estimate the parameters. Male mortality was more than twice the female mortality. The rates also varied by age and sex. The most frequent cause of mortality was traffic accidents and drowning for men and traffic accidents and suicide for women. Lower education of household heads in the neighborhood was an important risk factor for increased mortality. The mortality was highly variable in space and the socio-ecological risk factors are sensitive to study site and sex.
Our study suggests that lower education of the household head is an important predictor for prime age adult mortality. Variability in socio-ecological risk factors and in risk areas by sex make it challenging to design appropriate intervention strategies aimed at decreasing prime-age adult deaths in Vietnam.
分层空间模型能够对健康数据进行地理和生态分析,从而为设计有效的健康干预措施提供有用信息。在本研究中,我们使用贝叶斯分层空间模型来评估越南的死亡率数据。该模型能够识别社会生态风险因素并生成风险地图,以更好地理解青壮年(15至45岁以下)成人死亡的原因及地理影响。
该研究在越南的两个地点进行:芽庄和顺化。研究区域被划分为500×500米的单元格以定义社区。我们首先从两个地点的人口数据库中提取社会人口数据,然后按社区汇总数据。我们使用从邻居处借取强度的空间分层模型来评估风险因素,并在调整社区层面协变量后创建空间平滑的风险地图。采用马尔可夫链蒙特卡罗程序来估计参数。男性死亡率是女性死亡率的两倍多。死亡率也因年龄和性别而异。男性最常见的死亡原因是交通事故和溺水,女性是交通事故和自杀。社区中户主教育程度较低是死亡率增加的一个重要风险因素。死亡率在空间上高度可变,且社会生态风险因素对研究地点和性别敏感。
我们的研究表明,户主教育程度较低是青壮年成人死亡率的一个重要预测因素。社会生态风险因素和风险区域因性别而异,这使得设计旨在降低越南青壮年成人死亡的适当干预策略具有挑战性。