Teshima H, Masaoka T, Inoue T, Kato S, Naito K, Mori T, Kanamaru A, Saito Y, Ohira M, Moriyama Y
The Center for Adult Diseases, Osaka, Japan.
Bone Marrow Transplant. 1986 Dec;1(2):179-83.
One hundred and four patients with acute leukemia treated by allogeneic bone marrow transplantation in Japan were analysed for the incidence of interstitial pneumonitis (IP). Thirty-six (35%) of 104 marrow graft recipients developed IP. Cytomegalovirus (CMV) was the most frequent organism (61%). Using multivariate analysis, remission at transplant (P = 0.0001) and use of cyclosporin A to prevent graft-versus-host disease (P = 0.0363) were found to be significant factors associated with a decreased incidence of IP. For preventing IP, anti-CMV hyperimmune globulin was effective, while interferon and acyclovir were not.
对日本104例接受异基因骨髓移植治疗的急性白血病患者的间质性肺炎（IP）发病率进行了分析。104例骨髓移植受者中有36例（35%）发生了IP。巨细胞病毒（CMV）是最常见的病原体（61%）。通过多变量分析发现，移植时处于缓解期（P = 0.0001）以及使用环孢素A预防移植物抗宿主病（P = 0.0363）是与IP发病率降低相关的显著因素。对于预防IP，抗CMV高效价免疫球蛋白有效，而干扰素和阿昔洛韦则无效。
