Tissue Typing Laboratory, Rabin Medical Center, Petach-Tikva, Israel.
Am J Reprod Immunol. 2014 May;71(5):467-71. doi: 10.1111/aji.12213. Epub 2014 Mar 3.
Previous studies support a role for MHC on mating preference, yet it remains unsettled as to whether mating occurs preferentially between individuals sharing human leukocyte antigen (HLA) determinants or not. Investigating sex-mate preferences in the contemporary Israeli population is of further curiosity being a population with distinct genetic characteristics, where multifaceted cultural considerations influence mate selection.
Pairs of male-female sex partners were evaluated in three groups. Two groups represented unmarried (n = 1002) or married (n = 308) couples and a control group of fictitious male-female couples. HLA and short-tandem-repeat (STR) genetic identification markers were assessed for the frequency of shared antigens and alleles.
Human leukocyte antigen results showed that Class I and/ or Class II single antigen as well as double antigen sharing was more common in sex partners than in control group couples (P < 0.001). Married versus unmarried pairs were not distinguishable. In contrast, STR-DNA markers failed to differentiate between sex-mates and controls (P = 0.78).
Sex partnerships shared HLA determinants more frequently than randomly constituted male-female pairs. The observed phenomenon does not reflect a syngenetic background between sex-mates as STR markers were not selectively shared. Thus, sex-mate selection in man may contravene the evolutionary pressure for genetic diversity in regard to HLA.
先前的研究支持 MHC 在交配偏好中的作用，但仍然存在争议，即是否优先发生在共享人类白细胞抗原（HLA）决定簇的个体之间。在具有独特遗传特征的当代以色列人群中研究性伴侣偏好是进一步的好奇心，其中多方面的文化考虑因素影响伴侣选择。
在三组中评估了男性-女性性伴侣对。两组代表未婚（n=1002）或已婚（n=308）夫妇，以及虚构的男性-女性夫妇对照组。评估了 HLA 和短串联重复（STR）遗传识别标记，以确定共享抗原和等位基因的频率。
人类白细胞抗原结果表明，I 类和/或 II 类单一抗原以及双抗原共享在性伴侣中比在对照组夫妇中更为常见（P<0.001）。已婚和未婚对之间没有区别。相比之下，STR-DNA 标记未能区分性伴侣和对照组（P=0.78）。
性伴侣关系比随机组成的男性-女性对更频繁地共享 HLA 决定簇。观察到的现象并不反映性伴侣之间的同生背景，因为 STR 标记没有被选择性共享。因此，人类的性伴侣选择可能违反了 HLA 方面遗传多样性的进化压力。
