β淀粉样蛋白与认知变化：阿尔茨海默病的临床前和前驱期研究。
Aβ and cognitive change: examining the preclinical and prodromal stages of Alzheimer's disease.
机构信息
The Florey Institute of Neuroscience and Mental Health, Parkville, Victoria, Australia; Department of Psychiatry, The University of Melbourne, Parkville, Victoria, Australia.
The Florey Institute of Neuroscience and Mental Health, Parkville, Victoria, Australia; CogState Ltd., Melbourne, Victoria, Australia.
出版信息
Alzheimers Dement. 2014 Nov;10(6):743-751.e1. doi: 10.1016/j.jalz.2013.11.005. Epub 2014 Feb 28.
BACKGROUND
High β-amyloid (Aβ) is associated with faster memory decline in healthy individuals and adults with mild cognitive impairment (MCI). However, longer prospective studies are required to determine if Aβ-related memory decline continues and whether it is associated with increased rate of disease progression.
METHODS
Healthy controls (HCs; n = 177) and adults with MCI (n = 48) underwent neuroimaging for Aβ and cognitive assessment at baseline. Cognition was reassessed 18 and 36 months later.
RESULTS
Compared with low-Aβ HCs, high-Aβ HC and MCI groups showed moderate decline in episodic and working memory over 36 months. Those with MCI with low Aβ did not show any cognitive decline. Rates of disease progression were increased in the high-Aβ HC and MCI groups.
CONCLUSIONS
In healthy individuals, high Aβ likely indicates that Alzheimer's disease (AD)-related neurodegeneration has begun. Once commenced, the rate of decline in cognitive function remains constant across the preclinical and prodromal stages of AD.
背景
高β-淀粉样蛋白（Aβ）与健康个体和轻度认知障碍（MCI）成年人的记忆衰退速度加快有关。然而，需要进行更长时间的前瞻性研究，以确定 Aβ 相关的记忆衰退是否持续，以及它是否与疾病进展速度的增加有关。
方法
健康对照组（HC；n=177）和 MCI 成年人（n=48）在基线时进行 Aβ 神经影像学和认知评估。18 个月和 36 个月后重新评估认知。
结果
与低 Aβ 的 HC 相比，高 Aβ 的 HC 和 MCI 组在 36 个月内表现出情节记忆和工作记忆的中度衰退。那些低 Aβ 的 MCI 患者没有表现出任何认知衰退。高 Aβ 的 HC 和 MCI 组的疾病进展速度加快。
结论
在健康个体中，高 Aβ 可能表明与阿尔茨海默病（AD）相关的神经退行性变已经开始。一旦开始，认知功能的下降速度在 AD 的临床前和前驱期保持不变。
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