Buyukkaya R, Besir F H, Yazgan S, Karatas A, Kose S A, Aydin Y, Erdogmus B
Departments of Radiology, Duzce University, Medicine School, Duzce- Turkey.
Departments of Obstetrics and Gynecology, Duzce University, Medicine School, Duzce- Turkey.
Clin Ter. 2014;165(1):e6-11.
Polycystic ovary syndrome (PCOS) is a common endocrine disorder which is associated with multiple risk factors for atherosclerosis. The aim of this study was to investigate the CIMT which is used in the early diagnosis of atherosclerosis and visceral obesity by ultrasound in newly diagnosed polycystic ovary syndrome with normal body mass index.
A case-control study was conducted on 25 PCOS women (18-30 years of age) and 25 controls. BMI was matched volunteer controls. Carotid intima media thickness (CIMT) and fat distribution as visceral fat thickness (VFT) with subcutaneous fat thickness (SFT) were measured by ultrasound. After, visceral fat ratio (VFR) fat ratio (VFR) was calculated using VFT divided by SFT. The variables were compared using the χ(2)-test and Student's t test.
Comparing women with PCOS to the control group showed that CIMT was similar in both groups (p=0.84). The VFT in the PCOS group was higher than the control group (p=0.048). Whereas, the SFT was higher in the control group when compared to women with PCOS (p=0.007). The VFR was significantly higher in women with PCOS when compared to the control group (1.12 ± 0.38 vs. 0.81 ± 0.34; p=0.005).
CIMT which used as early atherosclerosis predictors have not increased in newly diagnosed PCOS women. Body fat distribution was observed in visceral area in the newly diagnosed PCOS women. VFR follow up may provide benefit as a quantitative method for the assessment and follow up of visceral obesity in women with PCOS.
多囊卵巢综合征（PCOS）是一种常见的内分泌紊乱疾病，与动脉粥样硬化的多种危险因素相关。本研究的目的是通过超声检查，对新诊断的体重指数正常的多囊卵巢综合征患者进行动脉粥样硬化和内脏肥胖的早期诊断，研究颈动脉内膜中层厚度（CIMT）。
对25例年龄在18 - 30岁的PCOS女性患者和25例对照者进行病例对照研究。BMI匹配志愿者作为对照。通过超声测量颈动脉内膜中层厚度（CIMT）以及作为内脏脂肪厚度（VFT）与皮下脂肪厚度（SFT）的脂肪分布。之后，用VFT除以SFT计算内脏脂肪比率（VFR）。使用χ(2)检验和学生t检验比较变量。
将PCOS女性与对照组进行比较，结果显示两组的CIMT相似（p = 0.84）。PCOS组的VFT高于对照组（p = 0.048）。然而，与PCOS女性相比，对照组的SFT更高（p = 0.007）。与对照组相比，PCOS女性的VFR显著更高（1.12±0.38对0.81±0.34；p = 0.005）。
作为早期动脉粥样硬化预测指标的CIMT在新诊断的PCOS女性中并未增加。在新诊断的PCOS女性中观察到内脏区域的体脂分布。VFR随访作为评估和随访PCOS女性内脏肥胖的定量方法可能有益。
