Department of Endocrinology and Metabolic Diseases, Diskapi Training and Research Hospital, Demetevler 1. cadde, 81-10, Altindag, TR-06200, Ankara, Turkey.
Atherosclerosis. 2013 Jan;226(1):291-5. doi: 10.1016/j.atherosclerosis.2012.11.004. Epub 2012 Nov 15.
Polycystic ovary syndrome (PCOS) is one of the most common endocrine disorders affecting reproductive-age women and is reported to be associated with an increased risk of cardiovascular disease and early atherosclerosis. Epicardial fat thickness (EF) is clinically related to subclinical atherosclerosis and visceral fat changes. Therefore, the objective of this study is to compare the carotid artery intima-media thickness (CIMT), EF and cardiometabolic risk factors in patients with PCOS, patients with idiopathic hirsutism (IH) and healthy controls.
This cross-sectional controlled study was conducted in a training and research hospital. The study population consisted of 50 reproductive-age PCOS women, 34 women with IH and 39 control subjects. We evaluated anthropometric, hormonal and metabolic parameters as well as CIMT and EF measurements in PCOS patients, IH patients and controls.
The mean fasting insulin, HOMA-IR, hsCRP, GGT, CIMT, and EF levels were significantly higher in patients with PCOS and IH (p < 0.05). A significant positive correlation was found between EF and age, BMI, WHR, Ferriman Gallwey score (FG), fasting insulin, HOMA-IR, triglyceride, total cholesterol, LDL-C, 17 OH progesterone, free testosterone, CIMT, hsCRP, and GGT, whereas a significant negative correlation was observed between EF and HDL-C (p < 0.05). In the multiple linear regression analyses, EF was found to be associated with the FG (β coefficient: 0.389, p < 0.001), CIMT (β coefficient: 0.376, p < 0.001) and free testosterone levels (β coefficient: 0.173, p < 0.038).
EF appears to be a marker that will enable the detection of the cardiometabolic response in patients with PCOS and IH, even at an early stage.
多囊卵巢综合征（PCOS）是影响育龄妇女的最常见内分泌疾病之一，据报道其与心血管疾病和早期动脉粥样硬化的风险增加有关。心外膜脂肪厚度（EF）与亚临床动脉粥样硬化和内脏脂肪变化密切相关。因此，本研究旨在比较多囊卵巢综合征患者、特发性多毛症（IH）患者和健康对照组的颈动脉内膜中层厚度（CIMT）、EF 和心脏代谢危险因素。
这是一项在培训和研究医院进行的横断面对照研究。研究人群包括 50 名育龄期 PCOS 女性、34 名 IH 女性和 39 名对照组。我们评估了 PCOS 患者、IH 患者和对照组的人体测量、激素和代谢参数以及 CIMT 和 EF 测量值。
PCOS 和 IH 患者的空腹胰岛素、HOMA-IR、hsCRP、GGT、CIMT 和 EF 水平显著升高（p<0.05）。EF 与年龄、BMI、腰臀比、Ferriman-Gallwey 评分（FG）、空腹胰岛素、HOMA-IR、甘油三酯、总胆固醇、LDL-C、17-羟孕酮、游离睾酮、CIMT、hsCRP 和 GGT 呈显著正相关，而与 HDL-C 呈显著负相关（p<0.05）。多元线性回归分析显示，EF 与 FG（β系数：0.389，p<0.001）、CIMT（β系数：0.376，p<0.001）和游离睾酮水平（β系数：0.173，p<0.038）相关。
EF 似乎是一种标志物，可用于检测 PCOS 和 IH 患者的心脏代谢反应，甚至在早期阶段。
