Klöcking H P, Schulze-Riewald H, Markwardt F
Institute of Pharmacology and Toxicology, Medical Academy Erfurt, GDR.
Folia Haematol Int Mag Klin Morphol Blutforsch. 1988;115(1-2):106-9.
The influence of hirudin on thrombus formation induced by prothrombin complex concentrate (PCC) was studied in two different test series in rats. Within the first test series hirudin was i.v. administered to the animals 10 min before they received PCC. Complete prevention of thrombus formation required a hirudin dose of 0.2 mg/kg. Within the second test series hirudin was added to the transfusion unit of PCC before application of PCC was started. In this case complete prevention of thrombus formation was yielded by addition of 140 micrograms hirudin to the PCC transfusion unit. In comparison with heparin and the synthetic thrombin inhibitor N alpha-(2-naphthylsulfonyl-glycyl)-4-amidinophenylalanine piperidide, hirudin was most potent.
在大鼠的两个不同测试系列中研究了水蛭素对凝血酶原复合物浓缩物（PCC）诱导的血栓形成的影响。在第一个测试系列中，在动物接受PCC前10分钟静脉注射水蛭素。完全预防血栓形成所需的水蛭素剂量为0.2mg/kg。在第二个测试系列中，在开始应用PCC之前将水蛭素添加到PCC的输血单元中。在这种情况下，向PCC输血单元中添加140微克水蛭素可完全预防血栓形成。与肝素和合成凝血酶抑制剂Nα-（2-萘磺酰基-甘氨酰基）-4-脒基苯丙氨酸哌啶相比，水蛭素的效果最强。
