Sumida Hayakazu, Asano Yoshihide, Hatano Masaru, Aozasa Naohiko, Toyama Tetsuo, Akamata Kaname, Miyazaki Miki, Taniguchi Takashi, Takahashi Takehiro, Ichimura Yohei, Noda Shinji, Kuwano Yoshihiro, Yanaba Koichi, Sato Shinichi
a Department of Dermatology , Faculty of Medicine, The University of Tokyo , Tokyo , Japan.
b Department of Cardiovascular Medicine , Graduate School of Medicine, The University of Tokyo , Tokyo , Japan.
Mod Rheumatol. 2016;26(3):454-7. doi: 10.3109/14397595.2014.885377. Epub 2014 Mar 4.
Systemic sclerosis (SSc) is characterized by disturbed blood circulation. The effect of ambrisentan, an endothelin-A receptor-selective antagonist, on impaired peripheral circulation in SSc remains largely elusive. Here we show SSc patients, whose clinical symptoms such as cyanosis and Raynaud's phenomenon, were ameliorated by the treatment with ambrisentan. Additionally, objective evaluations with thermography showed improvement of hand coldness in steady-state and cold challenge tests. Ambrisentan might have a potential to improve peripheral circulation in SSc.
系统性硬化症（SSc）的特征是血液循环紊乱。内皮素-A受体选择性拮抗剂安立生坦对SSc患者外周循环受损的影响在很大程度上仍不清楚。在此，我们展示了安立生坦治疗可改善SSc患者的临床症状，如发绀和雷诺现象。此外，热成像的客观评估显示，在稳态和冷刺激试验中手部寒冷状况有所改善。安立生坦可能具有改善SSc患者外周循环的潜力。
