National Cancer Institute, "Pascale" Foundation, Medical Physics Department, Via Mariano Semmola 1, 80100 Naples, Italy.
Anticancer Res. 2014 Mar;34(3):1233-8.
We propose a comparative dosimetric study of whole-breast hypofractionated radiation therapy using helical tomotherapy (HT) in supine position and 3-D conformal radiotherapy (3D-CRT) in prone position. Twelve patients undergoing breast-conserving therapy were retrospectively selected from October to December 2012. Specific dose-volume parameters were selected for the study. The target coverage was adequate in all patients for both techniques. Significant differences in lung dose distribution were observed: maximum dose (mean value over the 12 plans) was 23.41 Gy in HT plans and 6.65 Gy in 3D-CRT; V20 (i.e. the lung volume receiving 20 Gy) was 0.31% in HT plans and 0.0% in 3D-CRT plans. The mean dose to the heart was 5.57 Gy and 0.93 Gy, respectively. The differences between the two techniques were significant (p<0.05) only for some parameters. We noted better results in the prone position, but with HT, dose constraints were mentioned for the whole set of considered organs.
我们提出了一种使用螺旋断层放疗（HT）在仰卧位和三维适形放疗（3D-CRT）在俯卧位进行全乳部分分放疗的比较剂量学研究。从 2012 年 10 月至 12 月，我们回顾性地选择了 12 名接受保乳治疗的患者。选择了特定的剂量体积参数进行研究。对于两种技术，所有患者的靶区覆盖率均足够。观察到肺剂量分布存在显著差异：HT 计划中的最大剂量（12 个计划中的平均值）为 23.41Gy，3D-CRT 计划中的最大剂量为 6.65Gy；HT 计划中的 V20（即接受 20Gy 的肺体积）为 0.31%，3D-CRT 计划中的 V20 为 0.0%。心脏的平均剂量分别为 5.57Gy 和 0.93Gy。两种技术之间的差异仅在某些参数上具有统计学意义（p<0.05）。我们注意到俯卧位的结果更好，但对于考虑的所有器官集，HT 的剂量限制均有所提及。
