Department of Laboratory Medicine, Toneyama National Hospital, 1-1, Toneyama 5-Chome, Toyonaka, Osaka, 560-8552 Japan.
Anticancer Res. 2014 Mar;34(3):1251-3.
BACKGROUND/AIM: Survivin is expressed in the nucleus and/or cytoplasm of various types of malignant tumor cells. Nuclear survivin is indispensable for complete mitosis, while cytoplasmic survivin functions as an apoptosis inhibitor. We examined the difference in the survivin expression among stromal cells of fibroadenoma, and benign and malignant phyllodes tumors.
Tumor sections were immunohistochemically stained with an anti-human survivin antibody and the labeling index of survivin was calculated.
In stromal cells of all tumors, survivin was expressed in the nuclei but not in the cytoplasm. The labeling indices of the stromal cells in five malignant phyllodes tumors (20.5±3.0) were significantly greater than those observed in eight fibroadenomas (1.9±0.6) or nine benign phyllodes tumors (3.0±0.9).
In the present study it was shown that stromal cells in malignant phyllodes tumors express nuclear survivin more extensively than stromal cells in benign phyllodes tumors or fibroadenomas.
背景/目的：Survivin 存在于各种类型的恶性肿瘤细胞的核内和/或细胞质中。核内 Survivin 对于完成有丝分裂是不可或缺的，而细胞质 Survivin 则作为凋亡抑制剂发挥作用。我们检测了纤维腺瘤、良性和恶性叶状肿瘤间质细胞中 Survivin 表达的差异。
使用抗人 Survivin 抗体对肿瘤切片进行免疫组织化学染色，并计算 Survivin 的标记指数。
所有肿瘤的间质细胞中，Survivin 仅表达在细胞核中，而不存在于细胞质中。在 5 例恶性叶状肿瘤的间质细胞中（20.5±3.0），标记指数明显高于 8 例纤维腺瘤（1.9±0.6）或 9 例良性叶状肿瘤（3.0±0.9）。
本研究表明，恶性叶状肿瘤的间质细胞比良性叶状肿瘤或纤维腺瘤的间质细胞更广泛地表达核内 Survivin。
