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硼替佐米诱发的多发性骨髓瘤患者疼痛性神经病变

Bortezomib-induced painful neuropathy in patients with multiple myeloma.

作者信息

Bilińska Małgorzata, Usnarska-Zubkiewicz Lidia, Pokryszko-Dragan Anna

机构信息

Department of Neurology, Wroclaw Medical University, Wroclaw, Poland.

Department of Haematology, Blood Neoplasms and Bone Marrow Transplantation, Wroclaw Medical University, Wroclaw, Poland.

出版信息

Contemp Oncol (Pozn). 2013;17(5):421-6. doi: 10.5114/wo.2013.37214. Epub 2013 Oct 11.

Abstract

Neurotoxicity towards the peripheral nervous system which appears clinically in the form of painful neuropathy is an essential dose-limiting factor during the treatment of multiple myeloma. In this review article different forms of this painful neuropathy are presented together with currently available diagnostic tools which are usually applied to confirm the diagnosis. Also, the most often used neurological scales estimating neurological deficit are presented. Special attention is paid to the management of the reversibility of bortezomib-induced neuropathic pain.

摘要

对周围神经系统的神经毒性在临床上表现为疼痛性神经病变,是多发性骨髓瘤治疗过程中的一个重要剂量限制因素。在这篇综述文章中,介绍了这种疼痛性神经病变的不同形式以及目前用于确诊的可用诊断工具。此外,还介绍了最常用的评估神经功能缺损的神经学量表。特别关注了硼替佐米诱导的神经性疼痛可逆性的管理。

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