牛甲状旁腺细胞中异常的钙激活钾通道。
Unusual calcium-activated potassium channels of bovine parathyroid cells.
作者信息
Jia M, Ehrenstein G, Iwasa K
机构信息
Laboratory of Biophysics, National Institute of Neurological and Communicative Disorders and Stroke, Bethesda, MD 20892.
出版信息
Proc Natl Acad Sci U S A. 1988 Oct;85(19):7236-9. doi: 10.1073/pnas.85.19.7236.
Abstract
Parathyroid cells have unusual responses to an increase in the external calcium concentration--a reduction in secretion and a depolarization. In an attempt to explain this behavior, we have studied voltage-clamped inside-out patches from bovine parathyroid cells. We found a potassium-selective channel that requires internal calcium to open and has a 175-pS conductance. This channel differs from calcium-activated potassium channels that have been found in other cells in that it closes when the internal calcium concentration is increased above about 160 nM. This channel can account for the depolarization that occurs in parathyroid cells in high-calcium solutions. It may also account for the reduced secretion in high-calcium solutions.
摘要
甲状旁腺细胞对外界钙浓度升高有异常反应——分泌减少和去极化。为了解释这种行为，我们研究了来自牛甲状旁腺细胞的电压钳制内向外膜片。我们发现了一种钾选择性通道，它需要细胞内钙来打开，电导为175皮西门子。该通道与在其他细胞中发现的钙激活钾通道不同，当细胞内钙浓度增加到约160纳摩尔以上时它会关闭。该通道可以解释高钙溶液中甲状旁腺细胞发生的去极化。它也可能解释高钙溶液中分泌减少的原因。
相似文献
1
Unusual calcium-activated potassium channels of bovine parathyroid cells.牛甲状旁腺细胞中异常的钙激活钾通道。
Proc Natl Acad Sci U S A. 1988 Oct;85(19):7236-9. doi: 10.1073/pnas.85.19.7236.
2
Ca2+- and voltage-dependent K+ conductance in dispersed parathyroid cells.分散甲状旁腺细胞中钙和电压依赖性钾电导
Cell Calcium. 1987 Oct;8(5):377-83. doi: 10.1016/0143-4160(87)90012-1.
3
Calcium- and voltage-activated potassium channels in human macrophages.人类巨噬细胞中的钙激活和电压激活钾通道
Biophys J. 1984 Dec;46(6):821-5. doi: 10.1016/S0006-3495(84)84080-1.
4
Intracellular Ca(2+)-activated K+ channels modulated by variations in extracellular Ca2+ in dispersed bovine parathyroid cells.细胞外Ca2+变化对分散的牛甲状旁腺细胞中细胞内Ca(2+)激活的K+通道的调节作用
Endocrinology. 1995 May;136(5):2238-43. doi: 10.1210/endo.136.5.7720673.
5
Single-channel analysis of the potassium permeability in HeLa cancer cells: evidence for a calcium-activated potassium channel of small unitary conductance.HeLa癌细胞钾通透性的单通道分析：小单通道电导钙激活钾通道的证据
J Membr Biol. 1986;92(3):269-82. doi: 10.1007/BF01869395.
6
A calcium-activated cation-selective channel in rat cultured Schwann cells.大鼠培养雪旺细胞中的一种钙激活阳离子选择性通道。
Proc R Soc Lond B Biol Sci. 1984 Sep 22;222(1228):349-55. doi: 10.1098/rspb.1984.0068.
7
Two types of voltage-dependent potassium channels in outer hair cells from the guinea pig cochlea.豚鼠耳蜗外毛细胞中的两种电压依赖性钾通道。
Am J Physiol. 1999 Nov;277(5):C913-25. doi: 10.1152/ajpcell.1999.277.5.C913.
8
Multiple types of voltage-dependent Ca2+-activated K+ channels of large conductance in rat brain synaptosomal membranes.大鼠脑突触体膜中多种类型的大电导电压依赖性钙激活钾通道。
Biophys J. 1988 Jun;53(6):919-34. doi: 10.1016/S0006-3495(88)83173-4.
9
Control of PTH secretion is mediated through calcium channels and is blocked by pertussis toxin treatment of parathyroid cells.
Biochem Biophys Res Commun. 1986 Jul 31;138(2):960-5. doi: 10.1016/s0006-291x(86)80589-7.
10
Calcium-activated cation channel in rat thyroid follicular cells.
Biochim Biophys Acta. 1985 Dec 5;821(2):229-32. doi: 10.1016/0005-2736(85)90091-4.
引用本文的文献
1
High extracellular Ca2+ stimulates Ca2+-activated Cl- currents in frog parathyroid cells through the mediation of arachidonic acid cascade.高细胞外 Ca2+ 通过花生四烯酸级联反应介导，刺激蛙甲状旁腺细胞中的 Ca2+-激活 Cl- 电流。
PLoS One. 2011 Apr 29;6(4):e19158. doi: 10.1371/journal.pone.0019158.
2
Molecular basis of fast inactivation in voltage and Ca2+-activated K+ channels: a transmembrane beta-subunit homolog.电压门控和钙激活钾通道快速失活的分子基础：一种跨膜β亚基同源物。
Proc Natl Acad Sci U S A. 1999 Mar 30;96(7):4137-42. doi: 10.1073/pnas.96.7.4137.
3
Activity-dependent modulation of the presynaptic potassium current in the frog neuromuscular junction.青蛙神经肌肉接头处突触前钾电流的活动依赖性调节
J Physiol. 1996 Sep 15;495 ( Pt 3)(Pt 3):717-32. doi: 10.1113/jphysiol.1996.sp021628.
4
X-ray microanalysis of elemental changes in human parathyroid glands in primary and secondary hyperparathyroidism.原发性和继发性甲状旁腺功能亢进患者甲状旁腺元素变化的X射线微量分析
Histochem Cell Biol. 1996 Jun;105(6):467-73. doi: 10.1007/BF01457660.
5
Intracellular Ca2+ inactivates an outwardly rectifying K+ current in human adenomatous parathyroid cells.细胞内钙离子使人类腺瘤性甲状旁腺细胞中的外向整流钾电流失活。
Pflugers Arch. 1994 Feb;426(3-4):320-7. doi: 10.1007/BF00374788.
6
Interactions among calcium compartments in C6 rat glioma cells: involvement of potassium channels.C6大鼠胶质瘤细胞中钙区室间的相互作用：钾通道的参与
J Physiol. 1994 Jul 15;478 ( Pt 2)(Pt 2):251-63. doi: 10.1113/jphysiol.1994.sp020247.
7
Calcium-activated potassium channels: regulation by calcium.钙激活钾通道：钙的调节作用
J Bioenerg Biomembr. 1991 Aug;23(4):537-60. doi: 10.1007/BF00785810.
本文引用的文献
1
Depolarizing response of rat parathyroid cells to divalent cations.大鼠甲状旁腺细胞对二价阳离子的去极化反应。
J Gen Physiol. 1983 Aug;82(2):269-94. doi: 10.1085/jgp.82.2.269.
2
Relationship between parathyroid hormone secretion and cytosolic calcium concentration in dispersed bovine parathyroid cells.分散的牛甲状旁腺细胞中甲状旁腺激素分泌与胞质钙浓度之间的关系
Proc Natl Acad Sci U S A. 1984 May;81(10):3113-7. doi: 10.1073/pnas.81.10.3113.
3
Kinetics of Ca2+-activated K+ channels from rabbit muscle incorporated into planar bilayers. Evidence for a Ca2+ and Ba2+ blockade.整合到平面双层膜中的兔肌肉钙激活钾通道的动力学。钙和钡阻断的证据。
J Gen Physiol. 1983 Oct;82(4):543-68. doi: 10.1085/jgp.82.4.543.
4
Quantification of Ca2+-activated K+ channels under hormonal control in pig pancreas acinar cells.猪胰腺腺泡细胞中激素控制下钙激活钾通道的定量分析。
Nature. 1983;305(5931):228-32. doi: 10.1038/305228a0.
5
Single calcium-dependent potassium channels in clonal anterior pituitary cells.克隆的垂体前叶细胞中的单钙依赖性钾通道。
Biophys J. 1982 Sep;39(3):313-7. doi: 10.1016/S0006-3495(82)84522-0.
6
Improved patch-clamp techniques for high-resolution current recording from cells and cell-free membrane patches.用于从细胞和无细胞膜片进行高分辨率电流记录的改进膜片钳技术。
Pflugers Arch. 1981 Aug;391(2):85-100. doi: 10.1007/BF00656997.
7
PTH secretion in vivo and in vitro. Regulation by calcium and other secretagogues.
Miner Electrolyte Metab. 1982 Sep-Oct;8(3-4):130-50.
8
Regulation of parathyroid hormone secretion: proportional control by calcium, lack of effect of phosphate.甲状旁腺激素分泌的调节：受钙的比例控制，不受磷酸盐影响。
Endocrinology. 1968 Nov;83(5):1043-51. doi: 10.1210/endo-83-5-1043.
9
The sensitivity of Helix aspersa neurones to injected calcium ions.庭院蜗牛神经元对注入钙离子的敏感性。
J Physiol. 1974 Mar;237(2):259-77. doi: 10.1113/jphysiol.1974.sp010481.
10
Prostaglandin F2 alpha and alpha-adrenergic agonists regulate parathyroid cell function via the inhibitory guanine nucleotide regulatory protein.
Endocrinology. 1986 May;118(5):2115-9. doi: 10.1210/endo-118-5-2115.
Zotero 插件