Sandvik A K, Waldum H L
Dept. of Medicine, Trondheim University, Norway.
Scand J Gastroenterol. 1988 Aug;23(6):696-700. doi: 10.3109/00365528809093935.
The effects of the prostaglandin E1 analogue misoprostol on base-line and stimulated (gastrin, histamine, and the muscarinic M1 agonist McN-A-343) acid secretion, base-line and gastrin-stimulated histamine release, and base-line and McN-A-343-stimulated gastrin release in the totally isolated, vascularly perfused rat stomach were studied. At a concentration of 1 nM, misoprostol significantly (p less than 0.01) inhibited base-line acid secretion from 13.7 +/- 2.7 to 4.8 +/- 0.7 mumol/60 min, histamine-stimulated acid secretion from 99.9 +/- 15.1 to 21.8 +/- 8.2 mumol/60 min, maximal gastrin-stimulated secretion from 92.5 +/- 11.4 to 3.1 +/- 0.6 mumol/60 min, and maximal McN-A-343-stimulated secretion from 60.0 +/- 8.9 to 6.8 +/- 2.6 mumol/60 min (mean +/- SEM). Likewise, misoprostol significantly inhibited base-line vascular histamine release (p less than 0.05) from 10.1 +/- 2.3 to 3.7 +/- 0.7 nmol/60 min and gastrin-stimulated release (p less than 0.01) from 54.7 +/- 7.9 to 20.2 +/- 4.1 nmol/60 min (mean +/- SEM). The gastrin release was not affected by misoprostol. We conclude that misoprostol inhibits acid secretion both by a direct effect on the parietal cell and by inhibiting endogenous histamine release.
研究了前列腺素E1类似物米索前列醇对完全孤立、血管灌注大鼠胃的基础胃酸分泌和刺激（胃泌素、组胺及毒蕈碱M1激动剂McN-A-343）胃酸分泌、基础组胺释放和胃泌素刺激组胺释放以及基础胃泌素释放和McN-A-343刺激胃泌素释放的影响。在1 nM浓度下，米索前列醇显著（p<0.01）抑制基础胃酸分泌，从13.7±2.7降至4.8±0.7 μmol/60分钟，组胺刺激的胃酸分泌从99.9±15.1降至21.8±8.2 μmol/60分钟，最大胃泌素刺激的分泌从92.5±11.4降至3.1±0.6 μmol/60分钟，最大McN-A-343刺激的分泌从60.0±8.9降至6.8±2.6 μmol/60分钟（均值±标准误）。同样，米索前列醇显著抑制基础血管组胺释放（p<0.05），从10.1±2.3降至3.7±0.7 nmol/60分钟，以及胃泌素刺激的释放（p<0.01），从54.7±7.9降至20.2±4.1 nmol/60分钟（均值±标准误）。胃泌素释放不受米索前列醇影响。我们得出结论，米索前列醇通过对壁细胞的直接作用和抑制内源性组胺释放来抑制胃酸分泌。
