茫然和困惑：日常认知失败的分子遗传学方法。
Dazed and confused: a molecular genetic approach to everyday cognitive failure.
机构信息
Department of Psychology, University of Bonn, Bonn, Germany; Laboratory for Neurogenetics, University of Bonn, Bonn, Germany; Center for Economics and Neuroscience, University of Bonn, Bonn, Germany.
Department of Psychology, University of Bonn, Bonn, Germany; Laboratory for Neurogenetics, University of Bonn, Bonn, Germany; Center for Economics and Neuroscience, University of Bonn, Bonn, Germany.
出版信息
Neurosci Lett. 2014 Apr 30;566:216-20. doi: 10.1016/j.neulet.2014.02.052. Epub 2014 Mar 2.
An individual's susceptibility to everyday cognitive failure constitutes a risk factor for physical and mental health. Different factors such as inefficiency of executive functioning and high trait impulsivity have been shown to affect this susceptibility. Furthermore, twin studies indicate a high heritability of failure susceptibility revealing genetic variables as an important biological influence. We tested for a molecular genetic association between variants on the dopamine D2 receptor gene (DRD2), which relate to executive control and impulsivity, and susceptibility to everyday cognitive failure as assessed by the cognitive failure questionnaire (CFQ) in a sample of N=500 (n=140 male, n=360 female, mean age M=24.62, SD=7.98) healthy participants of central European descent. Moreover, we assessed whether trait impulsivity as measured by the Barratt impulsiveness scale (BIS-11) qualifies as a mediator between DRD2 variants and CFQ scores. We found a positive association between DRD2 variants and the CFQ. This effect was in part yet not completely mediated by trait impulsivity. The DRD2 C/C variant constitutes a protective factor for the susceptibility to everyday cognitive failure. Results point towards at least two biopsychological pathways that may explain the observed effect.
个体日常认知失败的易感性是身心健康的一个风险因素。研究表明，执行功能效率低下和高特质冲动等不同因素会影响这种易感性。此外，双胞胎研究表明，失败易感性的遗传性很高，这表明遗传变量是一个重要的生物学影响因素。我们在一个由 500 名（男性 140 名，女性 360 名，平均年龄 M=24.62，标准差 SD=7.98）中欧血统的健康参与者样本中，测试了多巴胺 D2 受体基因（DRD2）变体与认知失败问卷（CFQ）评估的日常认知失败易感性之间的分子遗传关联，该基因与执行控制和冲动有关。此外，我们评估了巴瑞特冲动量表（BIS-11）测量的特质冲动是否可以作为 DRD2 变体和 CFQ 分数之间的中介。我们发现 DRD2 变体与 CFQ 之间存在正相关。这种影响部分但并非完全由特质冲动介导。DRD2 C/C 变体是对日常认知失败易感性的保护因素。结果指出了至少两种可能解释观察到的效应的生物心理学途径。
Zotero 插件